A measure for characterizing sliding on lung boundaries.
A measure for characterizing sliding on lung boundaries.
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DOI：
10.1007/s10439-013-0920-5
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发表时间：
2014-03
影响因子：
3.8
通讯作者：
Raghavan, Madhavan L.
中科院分区：
文献类型：
--
作者：
Amelon, Ryan E.;Cao, Kunlin;Reinhardt, Joseph M.;Christensen, Gary E.;Raghavan, Madhavan L.
呼吸时，肺叶相对滑动。量化大叶滑动有助于更好地理解肺功能，更好地建模肺动力学，以及更好地理解裂隙附近图像配准的限制。本文提出了一种基于CT图像配准得到的位移场来表征肺叶滑动的新方法。当两个滑动裂片被建模为连续体时，裂缝处位移场的不连续将表现为最大剪切量的升高，该测量能够捕捉滑动的水平和方向。使用功能剩余容量（FRC）到总肺容量（TLC）扫描分析了6个人的肺。对肺叶进行逐叶分割和配准，得到位移场，由此计算所提出的滑动量。在薄壁组织中，滑动测量被发现是微不足道的，因为这里发生的组织剪切相对较少。另一方面，它沿着裂缝升高。因此，提出的整个肺滑动测量的地图清楚地描绘和量化肺叶之间的滑动。滑动是呼吸过程中肺部变形的一个关键方面。提出的措施可能有助于解决由用于放射治疗的变形分析技术中的滑动引入的伪影。
The lobes of the lungs slide relative to each other during breathing. Quantifying lobar sliding can aid in better understanding lung function, better modeling of lung dynamics, and a better understanding of the limits of image registration near fissures. We propose a novel measure to characterize lobe sliding in the lung based on the displacement field obtained from image registration of CT scans. When two sliding lobes are modeled as a continuum, the discontinuity in the displacement field at the fissure will manifest as elevated maximum shear – the proposed measure – which is capable of capturing both the level and orientation of sliding. Six human lungs were analyzed using scans spanning functional residual capacity (FRC) to total lung capacity (TLC). The lung lobes were segmented and registered on a lobe-by-lobe basis to obtain the displacement field from which the proposed sliding measure was calculated. The sliding measure was found to be insignificant in the parenchyma, as relatively little tissue shear occurs here. On the other hand, it was elevated along the fissures. Thus a map of the proposed sliding measure of the entire lung clearly delineates and quantifies sliding between lung lobes. Sliding is a key aspect of lung deformation during breathing. The proposed measure may help resolve artifacts introduced by sliding in deformation analysis techniques used for radiotherapy.
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