Manganese-induced atypical parkinsonism is associated with altered Basal Ganglia activity and changes in tissue levels of monoamines in the rat.
Manganese-induced atypical parkinsonism is associated with altered Basal Ganglia activity and changes in tissue levels of monoamines in the rat.
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DOI：
10.1371/journal.pone.0098952
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Benazzouz A
中科院分区：
文献类型：
--
作者：
Bouabid S;Delaville C;De Deurwaerdère P;Lakhdar-Ghazal N;Benazzouz A
锰的神经毒性与称为锰中毒的运动和认知障碍有关。然而，这些缺陷背后的机制仍然未知。在这里，我们研究了锰中毒对运动和非运动帕金森病样缺陷，如自发活动，运动协调，焦虑和“抑郁样”行为的影响。然后，我们研究了这种中毒对苍白球（GP）和丘脑底核（ENA）神经元活动的影响。在实验结束时，已经确定了三种单胺（多巴胺、去甲肾上腺素和5-羟色胺）的死后组织水平。实验在成年Sprague-Dawley大鼠中进行，每天用MnCl 2（10 mg/kg/，i. p.）5周。我们发现，锰逐步减少自发活动以及运动协调与焦虑和“抑郁样”行为的表现并行。电生理结果表明，虽然大多数的GP和ESTA神经元定期在控制，锰增加GP和ESTA神经元不规则放电和/或爆发的数量。生化结果表明，锰显着降低组织水平的去甲肾上腺素和5-羟色胺与增加代谢的多巴胺在纹状体。我们的数据提供的证据表明，锰中毒与单胺能系统的神经传递受损，这是在基底神经节神经元活动的变化和运动和非运动缺陷的表现，类似于在非典型帕金森氏症中观察到的起源。
Manganese neurotoxicity is associated with motor and cognitive disturbances known as Manganism. However, the mechanisms underlying these deficits remain unknown. Here we investigated the effects of manganese intoxication on motor and non-motor parkinsonian-like deficits such as locomotor activity, motor coordination, anxiety and “depressive-like” behaviors. Then, we studied the impact of this intoxication on the neuronal activity, the globus pallidus (GP) and subthalamic nucleus (STN). At the end of experiments, post-mortem tissue level of the three monoamines (dopamine, norepinephrine and serotonin) has been determined. The experiments were carried out in adult Sprague-Dawley rats, daily treated with MnCl2 (10 mg/kg/, i.p.) for 5 weeks. We show that manganese progressively reduced locomotor activity as well as motor coordination in parallel with the manifestation of anxiety and “depressive-like” behaviors. Electrophysiological results show that, while majority of GP and STN neurons discharged regularly in controls, manganese increased the number of GP and STN neurons discharging irregularly and/or with bursts. Biochemical results show that manganese significantly decreased tissue levels of norepinephrine and serotonin with increased metabolism of dopamine in the striatum. Our data provide evidence that manganese intoxication is associated with impaired neurotransmission of monoaminergic systems, which is at the origin of changes in basal ganglia neuronal activity and the manifestation of motor and non-motor deficits similar to those observed in atypical Parkinsonism.
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影响因子：
4.7
作者：
CHANDRA, SV;SHUKLA, GS
通讯作者：
SHUKLA, GS
DOI：
10.1196/annals.1306.009
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
Dobson, AW;Erikson, KM;Aschner, M
通讯作者：
Aschner, M
影响因子：
3.6
作者：
Diaz-Véliz, G;Mora, S;Segura-Aguilar, J
通讯作者：
Segura-Aguilar, J
影响因子：
3.7
作者：
Cordova FM;Aguiar AS Jr;Peres TV;Lopes MW;Gonçalves FM;Remor AP;Lopes SC;Pilati C;Latini AS;Prediger RD;Erikson KM;Aschner M;Leal RB
通讯作者：
Leal RB
影响因子：
4.5
作者：
AUTISSIER, N;ROCHETTE, L;BRALET, J
通讯作者：
BRALET, J