Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer.
Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer.
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静脉昆布褐藻糖胶鼻内治疗增强免疫检查点抑制剂介导的抗癌免疫力对抗转移性肺癌
DOI：
10.3390/ijms22179125
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发表时间：
2021-08-24
影响因子：
5.6
通讯作者：
Jin JO
中科院分区：
文献类型：
--
作者：
Zhang W;Hwang J;Yadav D;An EK;Kwak M;Lee PC;Jin JO
虽然岩藻依聚糖硫酸酯，一种研究充分的海藻提取的多糖，已显示出免疫刺激作用，引起抗癌免疫，粘膜佐剂作用，通过鼻内给药尚未进行研究。在这项研究中，通过鼻内给药检查了从腔水母提取的岩藻依聚糖（ECF）对肺中诱导抗癌免疫的作用。在C57 BL/6和BALB/c小鼠中，鼻内给予ECF促进了纵隔淋巴结（mLN）中树突状细胞（DCs）、自然杀伤（NK）细胞和T细胞的活化。ECF诱导的NK和T细胞活化由DC介导。此外，鼻内注射ECF增强了抗PD-L1抗体介导的对肺中B16黑色素瘤和CT-26癌肿瘤生长的抗癌活性，这需要细胞毒性T淋巴细胞和NK细胞。因此，这些数据表明，ECF作为粘膜佐剂发挥作用，增强免疫检查点抑制剂对转移性肺癌的免疫抑制作用。
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.
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