Escherichia coli adhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis.
Escherichia coli adhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis.
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DOI：
10.1136/jitc-2021-002666
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发表时间：
2021-07
影响因子：
10.9
通讯作者：
Jin JO
中科院分区：
文献类型：
--
作者：
Hwang J;Zhang W;Park HB;Yadav D;Jeon YH;Jin JO
先进的癌症治疗针对的是原发肿瘤和复发或转移的癌症。最近，联合治疗癌症对复发和转移的癌症显示出很高的效率。在本研究中，我们合成了一种含有免疫刺激重组蛋白FimH的热响应型杂化纳米颗粒(TRH)，用于诱导光热疗法(PTT)和免疫疗法的联合抗肿瘤及其转移。该杂化纳米粒子与近红外(NIR)吸收剂吲哚青绿复合，并在其表面修饰FimH形成F-TRH。通过PTT和免疫治疗相结合的方法，评价了F-TRH对小鼠CT-26肿瘤的抗癌和抗转移作用。近红外激光照射可引起F-TRH的温度升高，从而在体外诱导CT-26癌细胞的凋亡。此外，F-TRH和NIR激光照射促进了光热介导的对小鼠CT-26和4T1肿瘤的治疗作用。通过PTT从F-TRH释放FimH，以响应温度升高和癌细胞的凋亡小体，激发树突状细胞介导的癌症抗原特异性T细胞反应，从而抑制第二次挑战CT-26和4T1细胞在肺内的生长。这些数据显示了F-TRH在抗癌及其复发和转移的免疫光热治疗中的潜在应用。
Advanced cancer therapy is targeted at primary tumors and also recurrent or metastatic cancers. Combinational cancer treatment has recently shown high efficiency against recurrent and metastatic cancers. In this study, we synthesized a thermal responsive hybrid nanoparticle (TRH) containing FimH, an immune stimulatory recombinant protein, for the induction of a combination of photothermal therapy (PTT) and immunotherapy against cancer and its metastasis. The hybrid nanoparticle was incorporated with a near-infrared (NIR) absorbent, indocyanine green, and decorated with FimH on its surface to form F-TRH. F-TRH was evaluated for its anticancer and antimetastatic effects against CT-26 carcinoma in mice by combining PTT and immunotherapy. NIR laser irradiation elicited an elevation of temperature in F-TRH, which induced apoptosis in CT-26 carcinoma cells in vitro. In addition, F-TRH and NIR laser irradiation promoted photothermal-mediated therapeutic effects against CT-26 and 4T1 tumors in mice. The release of FimH from F-TRH in response to elevated temperature and apoptotic bodies of cancer cells via PTT elicited dendritic cell-mediated cancer antigen-specific T-cell responses, which subsequently inhibited the second challenge of CT-26 and 4T1 cell growth in the lung. These data demonstrate the potential use of F-TRH for immuno-photothermal therapy against cancer and its recurrence and metastasis.
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影响因子：
4.7
作者：
Husni P;Shin Y;Kim JC;Kang K;Lee ES;Youn YS;Rusdiana T;Oh KT
通讯作者：
Oh KT
影响因子：
5.8
作者：
Jin, Jun-O;Kwak, Minseok;Lee, Peter C. W.
通讯作者：
Lee, Peter C. W.
DOI：
10.1007/s00262-016-1823-8
发表时间：
2016-05
期刊：
Cancer immunology, immunotherapy : CII
影响因子：
--
作者：
Contreras A;Sen S;Tatar AJ;Mahvi DA;Meyers JV;Srinand P;Suresh M;Cho CS
通讯作者：
Cho CS
影响因子：
5.7
作者：
Lee, Song Yeul;Lee, Ruda;Park, Yong Il
通讯作者：
Park, Yong Il
影响因子：
7
作者：
Alving CR;Peachman KK;Rao M;Reed SG
通讯作者：
Reed SG