Abnormal cingulum bundle development in autism: a probabilistic tractography study.
Abnormal cingulum bundle development in autism: a probabilistic tractography study.
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DOI：
10.1016/j.pscychresns.2013.08.002
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发表时间：
2014-01-30
影响因子：
11.3
通讯作者：
Szeszko PR
中科院分区：
文献类型：
--
作者：
Ikuta T;Shafritz KM;Bregman J;Peters BD;Gruner P;Malhotra AK;Szeszko PR
现在有相当多的证据表明，白色物质异常在自闭症的神经生物学中发挥作用。然而，很少有研究致力于理解自闭症中典型的白色发育，以及这与在这种疾病中观察到的神经认知障碍的关系。在这项研究中，我们使用概率纤维束成像来识别21名患有自闭症谱系障碍（ASD）的青少年和年轻人以及21名年龄和性别匹配的健康志愿者的扣带回束。我们调查了年龄和分数各向异性之间关系的组间差异，分数各向异性是扣带束内白色物质完整性的一种假定测量。此外，在一个初步的调查中，我们检查扣带回分数各向异性和执行功能的行为评定量表（BRIEF）之间的关系。与正常发育的志愿者相比，ASD参与者的扣带束内各向异性分数显著降低。有一个显着的组与年龄的相互作用，ASD组没有显示出典型的年龄相关的增加，在健康个体中观察到的分数各向异性。此外，在ASD组中，扣带束内较低的各向异性分数与较差的BRIEF行为调节指数评分相关。目前的研究结果表明，扣带束白色物质的发展发生在青少年后期和成年早期的自闭症谱系障碍的失调，并建议，在这个轨迹更大的干扰与执行功能障碍的ASD。
There is now considerable evidence that white matter abnormalities play a role in the neurobiology of autism. Little research has been directed, however, at understanding (a)typical white matter development in autism and how this relates to neurocognitive impairments observed in the disorder. In this study we used probabilistic tractography to identify the cingulum bundle in 21 adolescents and young adults with autism spectrum disorder (ASD), and 21 age- and sex-matched healthy volunteers. We investigated group differences in the relationships between age and fractional anisotropy, a putative measure of white matter integrity, within the cingulum bundle. Moreover, in a preliminary investigation, we examined the relationship between cingulum fractional anisotropy and executive functioning using the Behavior Rating Inventory of Executive Function (BRIEF). The ASD participants demonstrated significantly lower fractional anisotropy within the cingulum bundle compared to the typically developing volunteers. There was a significant group-by-age interaction such that the ASD group did not show the typical age-associated increases in fractional anisotropy observed among healthy individuals. Moreover, lower fractional anisotropy within the cingulum bundle was associated with worse BRIEF behavioral regulation index scores in the ASD group. The current findings implicate a dysregulation in cingulum bundle white matter development occurring in late adolescence and early adulthood in autism spectrum disorder, and suggest that greater disturbances in this trajectory are associated with executive dysfunction in ASD.
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影响因子：
5.7
作者：
Jiao, Yun;Chen, Rong;Ke, Xiaoyan;Chu, Kangkang;Lu, Zuhong;Herskovits, Edward H.
通讯作者：
Herskovits, Edward H.
影响因子：
5.7
作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
通讯作者：
Lin, Ching-Po
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
影响因子：
4.7
作者：
Bolling, Danielle Z.;Pitskel, Naomi B.;Deen, Ben;Crowley, Michael J.;McPartland, James C.;Kaiser, Martha D.;Vander Wyk, Brent C.;Wu, Jia;Mayes, Linda C.;Pelphrey, Kevin A.
通讯作者：
Pelphrey, Kevin A.
影响因子：
3.5
作者：
Jou, R. J.;Mateljevic, N.;Pelphrey, K. A.
通讯作者：
Pelphrey, K. A.