Enhanced neural responses to rule violation in children with autism: a comparison to social exclusion.
Enhanced neural responses to rule violation in children with autism: a comparison to social exclusion.
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DOI：
10.1016/j.dcn.2011.02.002
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发表时间：
2011-07
影响因子：
4.7
通讯作者：
Pelphrey, Kevin A.
中科院分区：
文献类型：
--
作者：
Bolling, Danielle Z.;Pitskel, Naomi B.;Deen, Ben;Crowley, Michael J.;McPartland, James C.;Kaiser, Martha D.;Vander Wyk, Brent C.;Wu, Jia;Mayes, Linda C.;Pelphrey, Kevin A.
关键词：
本研究旨在探索自闭症谱系障碍(ASD)的两个特征缺陷：社会损害和限制性、重复行为模式的神经相关性。为此，我们使用社会排斥和违反规则的可比经验来探索ASD中潜在的非典型神经网络。在患有和不患有自闭症的儿童和青少年中，我们使用互动抛球游戏(Cyberball)来引发社会排斥，并使用类似的游戏(CyberShape)来引发非排他性规则违反。使用功能磁共振成像(FMRI)，我们确定了对社会排斥和违反规则的大脑反应的群体差异。虽然两组在隔离后都报告了同样的痛苦，但ASD儿童在隔离期间右脑岛和腹侧扣带前皮质活动不足。在违反规则的情况下，ASD患者右侧脑岛和背侧前额叶皮质过度活跃。在ASD组中，右侧脑岛在激活中表现为分离，在社会排斥状态下表现为低活动状态，在违反规则状态下表现为高活动状态。进一步探讨，右脑岛的不同区域在每一场比赛中都被调制，突出了区域特异性的差异，随后的分析揭示了功能连接模式的差异。这些结果表明，自闭症儿童在处理社会排斥和违反规则的过程中存在神经生物学差异。
The present study aimed to explore the neural correlates of two characteristic deficits in autism spectrum disorders (ASD); social impairment and restricted, repetitive behavior patterns. To this end, we used comparable experiences of social exclusion and rule violation to probe potentially atypical neural networks in ASD. In children and adolescents with and without ASD, we used the interactive ball-toss game (Cyberball) to elicit social exclusion and a comparable game (Cybershape) to elicit a non-exclusive rule violation. Using functional magnetic resonance imaging (fMRI), we identified group differences in brain responses to social exclusion and rule violation. Though both groups reported equal distress following exclusion, the right insula and ventral anterior cingulate cortex were hypoactive during exclusion in children with ASD. In rule violation, right insula and dorsal prefrontal cortex were hyperactive in ASD. Right insula showed a dissociation in activation; it was hypoactive to social exclusion and hyperactive to rule violation in the ASD group. Further probed, different regions of right insula were modulated in each game, highlighting differences in regional specificity for which subsequent analyses revealed differences in patterns of functional connectivity. These results demonstrate neurobiological differences in processing social exclusion and rule violation in children with ASD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
16.2
作者：
Grinband, J;Hirsch, J;Ferrera, VP
通讯作者：
Ferrera, VP
影响因子：
4.8
作者：
Goebel, R;Esposito, F;Formisano, E
通讯作者：
Formisano, E
影响因子：
5.7
作者：
Hennenlotter, A;Schroeder, U;Ceballos-Baumann, AO
通讯作者：
Ceballos-Baumann, AO
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.