Structured sampling of olfactory input by the fly mushroom body.
Structured sampling of olfactory input by the fly mushroom body.
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DOI：
10.1016/j.cub.2022.06.031
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发表时间：
2022-08-08
期刊：
影响因子：
9.2
通讯作者：
Bock, Davi D.
中科院分区：
文献类型：
--
作者：
Zheng, Zhihao;Li, Feng;Fisher, Corey;Ali, Iqbal J.;Sharifi, Nadiya;Calle-Schuler, Steven;Hsu, Joseph;Masoodpanah, Najla;Kmecova, Lucia;Kazimiers, Tom;Perlman, Eric;Nichols, Matthew;Li, Peter H.;Jain, Viren;Bock, Davi D.
黑腹果蝇的蘑菇体（MB）参与了关联记忆的形成和回忆。在MB到达后，感觉信息经历了深刻的转变，从广泛调谐和刻板的嗅觉投射神经元（PN）层的气味反应，狭窄的调谐和非刻板的反应在凯尼恩细胞（KCs）。理论和实验表明，这种转换是通过KC和PN之间的随机连接来实现的。然而，这一假设一直具有挑战性的测试，考虑到映射大量跨脑神经元之间的突触连接的困难。在这里，我们使用了最近的全脑电子显微镜体积的成年果蝇映射PN-KC连接在突触分辨率。PN-KC连接体揭示了意想不到的结构，主要食物反应PN类型在下游KC上以高于机会的水平聚集。过度收敛PN类型的轴突往往在MB主萼中彼此靠近，使得局部KC树突更有可能接收来自这些类型的输入。过度会聚的PN型优先与αβ和α ′ β ′ KC亚型的树突共树枝状连接。所观察到的网络的计算模拟显示退化的歧视性能相比，随机网络，除了当所有的信号流经过收敛，主要是食物响应PN类型。需要更多的理论和实验来充分描述观察到的非随机网络结构对联想记忆形成和回忆的影响。通过绘制果蝇（Drosophila melanogaster）全脑电子显微镜体积中的突触连接图，Zheng等人表明，对典型联想记忆回路的感觉输入不是随机采样的。相反，食物反应嗅觉投射神经元优先收敛到特定的凯尼恩细胞亚型。
Associative memory formation and recall in the fruit fly Drosophila melanogaster is subserved by the mushroom body (MB). Upon arrival in the MB, sensory information undergoes a profound transformation, from broadly tuned and stereotyped odorant responses in the olfactory projection neuron (PN) layer, to narrowly tuned and nonstereotyped responses in the Kenyon cells (KCs). Theory and experiment suggest this transformation is implemented by random connectivity between KCs and PNs. However, this hypothesis has been challenging to test, given the difficulty of mapping synaptic connections between large numbers of brain-spanning neurons. Here we used a recent whole-brain electron microscopy volume of the adult fruit fly to map PN-to-KC connectivity at synaptic resolution. The PN-KC connectome revealed unexpected structure, with preponderantly food-responsive PN types converging at above-chance levels on downstream KCs. Axons of the overconvergent PN types tended to arborize near one another in the MB main calyx, making local KC dendrites more likely to receive input from those types. Overconvergent PN types preferentially co-arborize and connect with dendrites of αβ and α’β’ KC subtypes. Computational simulation of the observed network showed degraded discrimination performance compared to a random network, except when all signal flowed through the overconvergent, primarily food-responsive PN types. Additional theory and experiment will be needed to fully characterize the impact of the observed nonrandom network structure on associative memory formation and recall. By mapping synaptic connectivity in a whole-brain electron microscopy volume of the fruit fly Drosophila melanogaster, Zheng et al. show that sensory input to a canonical associative memory circuit is not sampled at random. Rather, food-responsive olfactory projection neurons converge preferentially onto specific Kenyon cell subtypes.
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影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
7.7
作者：
Amin H;Apostolopoulou AA;Suárez-Grimalt R;Vrontou E;Lin AC
通讯作者：
Lin AC
DOI：
10.1523/jneurosci.2753-12.2013
发表时间：
2013-02-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barak O;Rigotti M;Fusi S
通讯作者：
Fusi S
影响因子：
64.8
作者：
Brown, Solange P.;Hestrin, Shaul
通讯作者：
Hestrin, Shaul
影响因子：
16.2
作者：
Clemens, Jan;Girardin, Cyrille C.;Murthy, Mala
通讯作者：
Murthy, Mala