Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
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DOI：
10.1038/nature07658
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发表时间：
2009-02-26
期刊：
影响因子：
64.8
通讯作者：
Hestrin, Shaul
中科院分区：
文献类型：
--
作者：
Brown, Solange P.;Hestrin, Shaul
皮层列产生单独的信息流，这些信息流分布到许多皮层和皮层下的大脑区域。我们问是否本地皮层内电路反映这些不同的处理流，通过测试，如果金字塔之间的皮层连接反映了他们的远程轴突目标。我们同时记录了多达四个逆行标记的锥体，这些锥体投射到上级丘、对侧纹状体或对侧皮质，以评估它们的突触连接。在这里，我们表明，突触连接的概率取决于突触前和突触后神经元的功能特性。我们首先发现，皮质纹状体锥体之间的单突触连接的频率显着高于皮质或皮质顶盖锥体。然后，我们表明，前馈连接的概率从corticcortex神经元corticotectal金字塔是大约三到四倍的概率高出corticcortex或corticotectal细胞之间的单突触连接。此外，我们发现突触前和突触后锥体的平均轴树重叠不能完全解释我们观察到的连接概率的差异。我们所描述的选择性突触相互作用表明，锥体细胞的局部网络的组织反映了突触前和突触后神经元的远程目标。
Cortical columns generate separate streams of information that are distributed to numerous cortical and subcortical brain regions. We asked whether local intracortical circuits reflect these different processing streams by testing if the intracortical connectivity among pyramids reflects their long-range axonal targets. We recorded simultaneously from up to four retrogradely labelled pyramids that projected to the superior colliculus, the contralateral striatum or the contralateral cortex to assess their synaptic connectivity. Here we show that the probability of synaptic connection depends on the functional identity of both the presynaptic and postsynaptic neurons. We first found that the frequency of monosynaptic connections among corticostriatal pyramids is significantly higher than among corticocortical or corticotectal pyramids. We then show that the probability of feedforward connections from corticocortical neurons to corticotectal pyramids is approximately three- to fourfold higher than the probability of monosynaptic connections among corticocortical or corticotectal cells. Moreover, we found that the average axodendritic overlap of the presynaptic and postsynaptic pyramids could not fully explain the differences in connection probability that we observed. The selective synaptic interactions we describe demonstrate that the organization of local networks of pyramidal cells reflects the long-range targets of both the presynaptic and postsynaptic neurons.
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