APRIL is overexpressed in cancer: link with tumor progression.
APRIL is overexpressed in cancer: link with tumor progression.
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APRIL 在癌症中过度表达：与肿瘤进展有关。
DOI：
10.1186/1471-2407-9-83
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发表时间：
2009-03-16
期刊：
影响因子：
3.8
通讯作者：
Klein, Bernard
中科院分区：
文献类型：
--
作者：
Moreaux, Jerome;Veyrune, Jean-Luc;De Vos, John;Klein, Bernard
BAFF和APRIL共有两种受体- TACI和BCMA -BAFF结合第三种受体BAFF-R。在血液恶性肿瘤中注意到BAFF和APRIL的表达增加。BAFF和APRIL对于正常和恶性B淋巴细胞的存活是必需的，并且在各种B细胞恶性肿瘤中已经报道了BAFF或APRIL或其受体（BCMA、TACI或BAFF-R）的改变的表达，所述B细胞恶性肿瘤包括B细胞非霍奇金淋巴瘤、慢性淋巴细胞性白血病、霍奇金淋巴瘤、多发性骨髓瘤和瓦尔登斯特伦巨球蛋白血症。我们使用公开的基因表达数据，包括Oncomine癌症微阵列数据库，比较了40种人类肿瘤类型（脑、上皮、淋巴、生殖细胞）中BAFF、APRIL、TACI和BAFF-R基因表达与其正常组织对应物的表达。我们发现TACI在多发性骨髓瘤和甲状腺癌中显著过表达，并且TACI表达与淋巴瘤预后相关。此外，BAFF和APRIL在许多癌症中过表达，我们表明APRIL表达与肿瘤进展相关。我们还发现，在APRIL过度表达或作为预后因子的肿瘤中，至少有一种蛋白聚糖与硫酸乙酰肝素链（HS）过度表达，HS是APRIL和TACI的共受体。APRIL可直接通过HS蛋白多糖诱导细胞存活或增殖。总之，这些数据表明，APRIL是一个潜在的预后因素，为一个大阵列的恶性肿瘤。
BAFF and APRIL share two receptors – TACI and BCMA – and BAFF binds to a third receptor, BAFF-R. Increased expression of BAFF and APRIL is noted in hematological malignancies. BAFF and APRIL are essential for the survival of normal and malignant B lymphocytes, and altered expression of BAFF or APRIL or of their receptors (BCMA, TACI, or BAFF-R) have been reported in various B-cell malignancies including B-cell non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's lymphoma, multiple myeloma, and Waldenstrom's macroglobulinemia. We compared the expression of BAFF, APRIL, TACI and BAFF-R gene expression in 40 human tumor types – brain, epithelial, lymphoid, germ cells – to that of their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray database. We found significant overexpression of TACI in multiple myeloma and thyroid carcinoma and an association between TACI expression and prognosis in lymphoma. Furthermore, BAFF and APRIL are overexpressed in many cancers and we show that APRIL expression is associated with tumor progression. We also found overexpression of at least one proteoglycan with heparan sulfate chains (HS), which are coreceptors for APRIL and TACI, in tumors where APRIL is either overexpressed or is a prognostic factor. APRIL could induce survival or proliferation directly through HS proteoglycans. Taken together, these data suggest that APRIL is a potential prognostic factor for a large array of malignancies.
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影响因子：
2.6
作者：
Briones, J;Timmerman, JM;Levy, R
通讯作者：
Levy, R
影响因子：
8
作者：
Farmer, P;Bonnefoi, H;Iggo, R
通讯作者：
Iggo, R
影响因子：
12.4
作者：
Hendriks, J;Planelles, L;Medema, JP
通讯作者：
Medema, JP
April是肿瘤坏死因子家族的新配体，刺激肿瘤细胞生长。
影响因子：
15.3
作者：
Hahne, M;Kataoka, T;Schroter, M;Hofmann, K;Irmler, M;Bodmer, J L;Schneider, P;Bornand, T;Holler, N;French, L E;Sordat, B;Rimoldi, D;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM