Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection.
Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection.
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DOI：
10.3389/fcvm.2021.757022
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发表时间：
2021
影响因子：
3.6
通讯作者：
Liu JC
中科院分区：
文献类型：
--
作者：
Huang H;Ye G;Lai SQ;Zou HX;Yuan B;Wu QC;Wan L;Wang Q;Zhou XL;Wang WJ;Cao YP;Huang JF;Chen SL;Yang BC;Liu JC
主动脉夹层是一种严重的心血管急症，预后差，且几乎没有前驱症状。脂代谢异常与AD的发病密切相关。然而，与AD发病机制相关的全面脂质改变仍不清楚。此外，迫切需要新的或更好的生物标志物来改善AD的风险评估和监测。因此，在本研究中，采用基于超高效液相色谱-质谱的非靶向脂质组学方法来揭示AD患者的血浆脂质组学改变和潜在的生物标志物。我们发现，278的439个确定的脂质种类显着改变AD患者（n = 35）相比，正常对照组（n = 32）。值得注意的是，大多数脂质种类，包括脂肪酸、酰基肉毒碱、胆固醇酯、神经酰胺、己糖基神经酰胺、鞘磷脂、溶血磷脂酰胆碱、溶血磷脂酰乙醇胺、磷脂酰胆碱、磷脂酰肌醇、二酰基甘油和三酰基甘油（总酰基链碳数≥54和/或总双键数≥4）减少，而总双键数<4的磷脂酰乙醇胺和三酰基甘油在AD患者中蓄积。此外，AD患者甘油三酯中酰基链的长度和不饱和度以及磷脂酰乙醇胺中1-酰基链的不饱和度降低。此外，溶血磷脂酰胆碱是最大的脂质变化，在相关网络的脂质变化的中心，并在识别AD患者有很好的性能。用溶血磷脂酰胆碱（20：0/0：0）或与溶血磷脂酰胆碱（17：0/0：0）或溶血磷脂酰胆碱（20：1/0：0）联用，其曲线下面积可达1.0，准确率可达100%。本研究为AD患者提供了新的、全面的血浆脂质组学特征，确定了溶血磷脂酰胆碱作为良好的潜在生物标志物，将有利于AD的发病机制研究、风险评估和及时诊断与治疗。
Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD. However, comprehensive lipid alterations related to AD pathogenesis remain unclear. Moreover, there is an urgent need for new or better biomarkers for improved risk assessment and surveillance of AD. Therefore, an untargeted lipidomic approach based on ultra-high-performance liquid chromatograph-mass spectrometry was employed to unveil plasma lipidomic alterations and potential biomarkers for AD patients in this study. We found that 278 of 439 identified lipid species were significantly altered in AD patients (n = 35) compared to normal controls (n = 32). Notably, most lipid species, including fatty acids, acylcarnitines, cholesteryl ester, ceramides, hexosylceramides, sphingomyelins, lysophosphatidylcholines, lysophosphatidylethanolamines, phosphatidylcholines, phosphatidylinositols, diacylglycerols, and triacylglycerols with total acyl chain carbon number ≥54 and/or total double bond number ≥4 were decreased, whereas phosphatidylethanolamines and triacylglycerols with total double bond number <4 accumulated in AD patients. Besides, the length and unsaturation of acyl chains in triacylglycerols and unsaturation of 1-acyl chain in phosphatidylethanolamines were decreased in AD patients. Moreover, lysophosphatidylcholines were the lipids with the largest alterations, at the center of correlation networks of lipid alterations, and had excellent performances in identifying AD patients. The area under the curve of 1.0 and accuracy rate of 100% could be easily obtained by lysophosphatidylcholine (20:0/0:0) or its combination with lysophosphatidylcholine (17:0/0:0) or lysophosphatidylcholine (20:1/0:0). This study provides novel and comprehensive plasma lipidomic signatures of AD patients, identifies lysophosphatidylcholines as excellent potential biomarkers, and would be beneficial to the pathogenetic study, risk assessment and timely diagnosis and treatment of AD.
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大规模代谢组分析确定了出现冠心病的新生物标志物。
影响因子：
4.5
作者：
Ganna A;Salihovic S;Sundström J;Broeckling CD;Hedman AK;Magnusson PK;Pedersen NL;Larsson A;Siegbahn A;Zilmer M;Prenni J;Arnlöv J;Lind L;Fall T;Ingelsson E
通讯作者：
Ingelsson E
主动脉夹层中的非编码 RNA：从生物标志物到治疗靶点
影响因子：
5.3
作者：
Cheng M;Yang Y;Xin H;Li M;Zong T;He X;Yu T;Xin H
通讯作者：
Xin H
DOI：
10.1093/bioinformatics/btq675
发表时间：
2011-02-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Smoot ME;Ono K;Ruscheinski J;Wang PL;Ideker T
通讯作者：
Ideker T
影响因子：
20.1
作者：
Rudolph V;Freeman BA
通讯作者：
Freeman BA
影响因子：
15.9
作者：
Schissel, SL;TweedieHardman, J;Tabas, I
通讯作者：
Tabas, I