Recent developments in yeast aging.

Recent developments in yeast aging.
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DOI:
10.1371/journal.pgen.0030084
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发表时间:
2007-05-25
期刊:
影响因子:
4.5
通讯作者:
Kennedy, Brian K.
Kennedy, Brian K.
中科院分区:
生物学2区
文献类型:
--
作者:
Kaeberlein, Matt;Burtner, Christopher R.;Kennedy, Brian K.

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在过去的十年中,对衰老的分子决定因素的研究进展迅速,其中大部分进展可以归因于对无脊椎真核模式生物的研究。其中,单细胞酵母是最不复杂的,最适合遗传和分子操作。支持使用这种生物体进行衰老研究,越来越多的证据表明,影响酵母寿命的途径的子集在其他真核生物中是保守的,包括哺乳动物。在这里,我们简要概述了酵母的衰老,并描述了最近的发现,继续保持这种“简单”的真核生物在衰老研究的前沿。
In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in invertebrate eukaryotic model organisms. Of these, single-celled yeast is the least complicated and most amenable to genetic and molecular manipulations. Supporting the use of this organism for aging research, increasing evidence has accumulated that a subset of pathways influencing longevity in yeast are conserved in other eukaryotes, including mammals. Here we briefly outline aging in yeast and describe recent findings that continue to keep this “simple” eukaryote at the forefront of aging research.
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