Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy.
Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy.
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用于光动力治疗中过氧化氢成像和自我治疗的化学发光纳米胶束
DOI：
10.1155/2011/679492
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发表时间：
2011
影响因子：
--
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Chen R;Zhang L;Gao J;Wu W;Hu Y;Jiang X
过氧化氢是肿瘤的信号分子，其过量产生使肿瘤组织中的浓度高于正常组织。基于过氧化氢存在下过草酸酯能高效地产生化学发光的事实，我们开发了由过草酸酯低聚物和荧光染料组成的纳米胶束，称为过草酸酯纳米胶束（POMs），它能以高灵敏度和稳定性对过氧化氢进行成像。探讨了多金属氧酸盐在肿瘤光动力治疗中的应用前景。结果表明，PDT药物负载的POM对过氧化氢敏感，且PDT药物可被POM与过氧化氢反应产生的化学发光所激发，从而在不需要外加激光光源的情况下对肿瘤进行自我治疗。
Hydrogen peroxide is a signal molecule of the tumor, and its overproduction makes a higher concentration in tumor tissue compared to normal tissue. Based on the fact that peroxalates can make chemiluminescence with a high efficiency in the presence of hydrogen peroxide, we developed nanomicelles composed of peroxalate ester oligomers and fluorescent dyes, called peroxalate nanomicelles (POMs), which could image hydrogen peroxide with high sensitivity and stability. The potential application of the POMs in photodynamic therapy (PDT) for cancer was also investigated. It was found that the PDT-drug-loaded POMs were sensitive to hydrogen peroxide, and the PDT drug could be stimulated by the chemiluminescence from the reaction between POMs and hydrogen peroxide, which carried on a self-therapy of the tumor without the additional laser light resource.
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