The NanoFlow Repository.
The NanoFlow Repository.
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DOI：
10.1093/bioinformatics/btad368
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发表时间：
2023-06-01
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影响因子：
--
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细胞外颗粒(EP)是一个快速增长的探索领域的焦点，因为人们对了解它们在健康和疾病中的作用产生了广泛的兴趣。然而，尽管普遍需要EP数据共享并建立了用于数据报告的社区标准，但是没有用于EP流式细胞仪数据的标准储存库捕获诸如由MIFlowCyt-EV(https://doi.org/10.1080/20013078.2020.1713526).定义的严格和最低报告标准我们试图通过开发纳米流储存库来解决这一未得到满足的需求。我们已经开发了Nanoflow Repository来提供MIFlowCyt-EV框架的第一个实现。纳米流库可免费获得，也可在线访问，网址为https://genboree.org/nano-ui/.公共数据集可在https://genboree.org/nano-ui/ld/datasets.上浏览和下载Nanoflow存储库的后端是使用为Clingen资源提供支持的Genboree软件堆栈构建的，特别是链接数据中心(Ldh)，这是一个用Node.js编写的rest API框架，最初开发的目的是在Clingen(https://ldh.clinicalgenome.org/ldh/ui/about).内聚合数据Nanoflow的乳酸脱氢酶(NanoAPI)可在https://genboree.org/nano-api/srvc.上购买。支持NanoAPI的有Node.js Genboree身份验证和授权服务(GbAuth)、名为ArangoDB的图形数据库以及管理流入NanoAPI的数据的ApachePulsar消息队列(NanoMQ)。Nanoflow Repository的网站是用Vue.js和Node.js(NanoUI)构建的，支持所有主要浏览器。
Extracellular particles (EPs) are the focus of a rapidly growing area of exploration due to the widespread interest in understanding their roles in health and disease. However, despite the general need for EP data sharing and established community standards for data reporting, no standard repository for EP flow cytometry data captures rigor and minimum reporting standards such as those defined by MIFlowCyt-EV (https://doi.org/10.1080/20013078.2020.1713526). We sought to address this unmet need by developing the NanoFlow Repository. We have developed The NanoFlow Repository to provide the first implementation of the MIFlowCyt-EV framework. The NanoFlow Repository is freely available and accessible online at https://genboree.org/nano-ui/. Public datasets can be explored and downloaded at https://genboree.org/nano-ui/ld/datasets. The NanoFlow Repository’s backend is built using the Genboree software stack that powers the ClinGen Resource, specifically the Linked Data Hub (LDH), a REST API framework written in Node.js, developed initially to aggregate data within ClinGen (https://ldh.clinicalgenome.org/ldh/ui/about). NanoFlow’s LDH (NanoAPI) is available at https://genboree.org/nano-api/srvc. NanoAPI is supported by a Node.js Genboree authentication and authorization service (GbAuth), a graph database called ArangoDB, and an Apache Pulsar message queue (NanoMQ) to manage data inflows into NanoAPI. The website for NanoFlow Repository is built with Vue.js and Node.js (NanoUI) and supports all major browsers.
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影响因子：
3.7
作者：
Spidlen, Josef;Moore, Wayne;Parks, David;Goldberg, Michael;Bray, Chris;Bierre, Pierre;Gorombey, Peter;Hyun, Bill;Hubbard, Mark;Lange, Simon;Lefebvre, Ray;Leif, Robert;Novo, David;Ostruszka, Leo;Treister, Adam;Wood, James;Murphy, Robert E.;Roederer, Mario;Sudar, Damir;Zigon, Robert;Brinkman, Ryan R.
通讯作者：
Brinkman, Ryan R.
影响因子：
3.7
作者：
Lee, Jamie A.;Spidlen, Josef;Boyce, Keith;Cai, Jennifer;Crosbie, Nicholas;Dalphin, Mark;Furlong, Jeff;Gasparetto, Maura.;Goldberg, Michael;Goralczyk, Elizabeth M.;Hyun, Bill;Jansen, Kirstin;Kollmann, Tobias;Kong, Megan;Leif, Robert;McWeeney, Shannon;Moloshok, Thomas D.;Moore, Wayne;Nolan, Garry;Nolan, John;Nikolich-Zugich, Janko;Parrish, David;Purcell, Barclay;Qian, Yu;Selvaraj, Biruntha;Smith, Clayton;Tchuvatkina, Olga;Wertheimer, Anne;WilkinSon, Peter;Wilson, Christopher;Wood, James;Zigon, Robert;Scheuermann, Richard H.;Brinkman, Ryan R.
通讯作者：
Brinkman, Ryan R.
影响因子：
3.7
作者：
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通讯作者：
Englyst, Nicola A.
影响因子：
46.9
作者：
Taylor, Chris F.;Field, Dawn;Sansone, Susanna-Assunta;Aerts, Jan;Apweiler, Rolf;Ashburner, Michael;Ball, Catherine A.;Binz, Pierre-Alain;Bogue, Molly;Booth, Tim;Brazma, Alvis;Brinkman, Ryan R.;Clark, Adam Michael;Deutsch, Eric W.;Fiehn, Oliver;Fostel, Jennifer;Ghazal, Peter;Gibson, Frank;Gray, Tanya;Grimes, Graeme;Hancock, John M.;Hardy, Nigel W.;Hermjakob, Henning;Julian, Randall K., Jr.;Kane, Matthew;Kettner, Carsten;Kinsinger, Christopher;Kolker, Eugene;Kuiper, Martin;Le Novere, Nicolas;Leebens-Mack, Jim;Lewis, Suzanna E.;Lord, Phillip;Mallon, Ann-Marie;Marthandan, Nishanth;Masuya, Hiroshi;McNally, Ruth;Mehrle, Alexander;Morrison, Norman;Orchard, Sandra;Quackenbush, John;Reecy, James M.;Robertson, Donald G.;Rocca-Serra, Philippe;Rodriguez, Henry;Rosenfelder, Heiko;Santoyo-Lopez, Javier;Scheuermann, Richard H.;Schober, Daniel;Smith, Barry;Snape, Jason;Stoeckert, Christian J., Jr.;Tipton, Keith;Sterk, Peter;Untergasser, Andreas;Vandesompele, Jo;Wiemann, Stefan
通讯作者：
Wiemann, Stefan
影响因子：
64.5
作者：
Murillo, Oscar D.;Thistlethwaite, William;Milosavljevic, Aleksandar
通讯作者：
Milosavljevic, Aleksandar