Dairy augmentation of total and central fat loss in obese subjects

Dairy augmentation of total and central fat loss in obese subjects
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乳制品可增加肥胖受试者的总脂肪和中心脂肪减少量

DOI:
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发表时间:
2005
影响因子:
4.9
通讯作者:
E. Silva
E. Silva
中科院分区:
医学2区
文献类型:
--
作者:
M. Zemel;J. Richards;S. Mathis;Anita Milstead;L. Gebhardt;E. Silva

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BACKGROUND AND OBJECTIVE: We have previously demonstrated an antiobesity effect of dietary Ca; this is largely mediated by Ca suppression of calcitriol levels, resulting in reduced adipocyte intracellular Ca2+ and, consequently, a coordinated increase in lipid utilization and decrease in lipogenesis. Notably, dairy Ca is markedly more effective than other Ca sources.DESIGN: Obese subjects were placed on balanced deficit (−500 kcal/day) diets and randomized to control (400–500 mg Ca/day; n=16) or yogurt (1100 mg Ca/day; n=18) treatments for 12 weeks. Dietary macronutrients and fiber were held constant at the US average.MEASUREMENTS: Body weight, body fat and fat distribution (by dual-energy X-ray absorptiometry), blood pressure and circulating lipids were measured at baseline and after 12 weeks of intervention.RESULTS: Fat loss was markedly increased on the yogurt diet (−4.43±0.47 vs −2.75±0.73 kg in yogurt and control groups; P<0.005) while lean tissue loss was reduced by 31% on the yogurt diet. Trunk fat loss was augmented by 81% on the yogurt vs control diet (P<0.001), and this was reflected in a markedly greater reduction in waist circumference (−3.99±0.48 vs −0.58±1.04 cm, P<0.001). Further, the fraction of fat lost from the trunk was higher on the yogurt diet vs control (P<0.005).CONCLUSION: Isocaloric substitution of yogurt for other foods significantly augments fat loss and reduces central adiposity during energy restriction.
DOI: 10.1093/jn/133.1.268s
发表时间: 2003-01-01
影响因子: 4.2
作者:
Heaney, RP
通讯作者: Heaney, RP
DOI: 10.1210/jcem.85.12.7063
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期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
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发表时间: 2003-07-01
影响因子: 15.9
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