HDL cholesterol and bone mineral density: is there a genetic link?
HDL cholesterol and bone mineral density: is there a genetic link?
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DOI：
10.1016/j.bone.2011.07.002
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发表时间：
2012-02
期刊：
影响因子：
4.1
通讯作者：
Ackert-Bicknell, Cheryl L.
中科院分区：
文献类型：
--
作者：
Ackert-Bicknell, Cheryl L.
压倒性的证据表明心血管疾病和骨质疏松症有关，但这两种老年疾病的共同根本原因仍然未知。低水平的高密度脂蛋白胆固醇（HDL）和骨矿物质密度（BMD）分别是心血管疾病和骨质疏松症的危险因素。许多相关性研究试图确定血清HDL和BMD之间是否存在关系，但这些研究受到许多变量的混淆，包括年龄，饮食，遗传背景，性别和激素状态。总的来说，这些数据表明这两种表型之间存在关系，但这种关系的性质是特定于环境的。在小鼠中的研究清楚地表明，BMD和HDL共图谱的遗传位点和转基因小鼠模型已被用于显示单个基因可以影响血清HDL和BMD。迄今为止完成的工作表明，HDL可以直接与成骨细胞和破骨细胞相互作用，但没有直接证据将骨与HDL水平的调节联系起来。了解BMD和HDL之间的遗传关系对于了解CVD和骨质疏松症之间的临床关系以及开发这两种疾病的安全治疗方案具有巨大意义。
Overwhelming evidence has linked cardiovascular disease and osteoporosis, but the shared root cause of these two diseases of the elderly remains unknown. Low levels of high-density lipoprotein cholesterol (HDL) and bone mineral density (BMD) are risk factors for cardiovascular disease and osteoporosis respectively. A number of correlation studies have attempted to determine if there is a relationship between serum HDL and BMD but these studies are confounded by a number of variables including age, diet, genetic background, gender and hormonal status. Collectively, these data suggest that there is a relationship between these two phenotypes, but that the nature of this relationship is context specific. Studies in mice plainly demonstrate that genetic loci for BMD and HDL co-map and transgenic mouse models have been used to show that a single gene can affect both serum HDL and BMD. Work completed to date has demonstrated that HDL can interact directly with both osteoblasts and osteoclasts, but no direct evidence links bone back to the regulation of HDL levels. Understanding the genetic relationship between BMD and HDL has huge implications for understanding the clinical relationship between CVD and osteoporosis and for the development of safe treatment options for both diseases.
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