Tumor-Associated Macrophages: Critical Players in Drug Resistance of Breast Cancer.
Tumor-Associated Macrophages: Critical Players in Drug Resistance of Breast Cancer.
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DOI：
10.3389/fimmu.2021.799428
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发表时间：
2021
影响因子：
7.3
通讯作者：
Shen Y
中科院分区：
文献类型：
--
作者：
Xiao M;He J;Yin L;Chen X;Zu X;Shen Y
耐药性是乳腺癌（BC）治疗中最关键的挑战之一。耐药的发生和发展与肿瘤免疫微环境（TIME）密切相关。肿瘤相关巨噬细胞（TAM）是TIME中最重要的免疫细胞，是BC治疗中耐药性的关键。本文综述了TAM对内分泌治疗、化疗、靶向治疗和免疫治疗中各种药物耐药性的影响及其机制。基于目前对TAMs在耐药中的关键作用的综述，我们讨论了在BC治疗中靶向TAMs以降低耐药的潜在可能性，通过抑制TAMs的募集，消耗TAMs的数量，调节TAMs的极化和增强TAMs的吞噬作用。我们综述中的证据支持开发新的治疗策略以靶向BC中的TAM以克服耐药性的治疗是重要的。
Drug resistance is one of the most critical challenges in breast cancer (BC) treatment. The occurrence and development of drug resistance are closely related to the tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs), the most important immune cells in TIME, are essential for drug resistance in BC treatment. In this article, we summarize the effects of TAMs on the resistance of various drugs in endocrine therapy, chemotherapy, targeted therapy, and immunotherapy, and their underlying mechanisms. Based on the current overview of the key role of TAMs in drug resistance, we discuss the potential possibility for targeting TAMs to reduce drug resistance in BC treatment, By inhibiting the recruitment of TAMs, depleting the number of TAMs, regulating the polarization of TAMs and enhancing the phagocytosis of TAMs. Evidences in our review support it is important to develop novel therapeutic strategies to target TAMs in BC to overcome the treatment of resistance.
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影响因子：
2.5
作者：
Dean, Michael
通讯作者：
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影响因子：
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作者：
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通讯作者：
van Pelt, Jos
DOI：
10.1016/j.bbamcr.2021.118995
发表时间：
2021-03-08
影响因子：
5.1
作者：
Ahmed, Shaza;Mohamed, Hossam Taha;Mohamed, Mona Mostafa
通讯作者：
Mohamed, Mona Mostafa