APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings.
APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings.
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DOI：
10.1371/journal.pone.0278115
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
非洲裔妇女极易患先兆子痫，这仍然是非洲产妇死亡的一个主要原因。APOL1基因的常见变异是一系列肾脏疾病的潜在危险因素。最近的研究表明，APOL1风险变异会增加子痫前期的风险。该研究的目的是了解APOL1风险变异对加纳孕妇先兆子痫发展的贡献。该研究是一项病例对照设计，于2019年在加纳科尔布教学医院开始招募。该研究将招募孕妇，目标招募700例先兆子痫患者和700例血压正常者。收集母婴双体的临床和人口统计学资料，包括脐带血和胎盘等生物标本，以评估子痫前期的临床、生化和遗传标记。研究方案已于2018年10月11日获得科勒布教学医院机构审查委员会（参考编号：KBTH-IRB/000108/2018）批准。截至2021年12月，共招募了773对母婴，其中大多数已经完整地输入数据进行分析。参与者包括384例先兆子痫患者和389例血压正常的母婴。患者的平均年龄为30.69±0.32岁，对照组为29.95±0.32岁。大多数参与者（85%）的年龄在20-30岁之间。在预约时，大多数患者血压正常，而在诊断时，85%的患者收缩压大于140mmHg， 82%的患者舒张压大于90mmHg。我们的研究最终将为子痫前期的风险分层和妊娠期间的仔细监测提供临床、生化和基因型数据，以改善临床管理和结局。
Women of African ancestry are highly predisposed to preeclampsia which continues to be a major cause of maternal death in Africa. Common variants in the APOL1 gene are potent risk factor for a spectrum of kidney disease. Recent studies have shown that APOL1 risk variants contribute to the risk of preeclampsia. The aim of the study is to understand the contribution of APOL1 risk variants to the development of preeclampsia in pregnant women in Ghana. The study is a case-control design which started recruitment in 2019 at the Korle Bu Teaching Hospital in Ghana. The study will recruit pregnant women with a target recruitment of 700 cases of preeclampsia and 700 normotensives. Clinical and demographic data of mother- baby dyad, with biospecimens including cord blood and placenta will be collected to assess clinical, biochemical and genetic markers of preeclampsia. The study protocol was approved by Korle Bu Teaching Hospital Institutional Review Board (Reference number: KBTH-IRB/000108/2018) on October 11, 2018. As of December 2021, a total of 773 mother-baby pairs had been recruited and majority of them had complete entry of data for analysis. The participants are made up of 384 preeclampsia cases and 389 normotensive mother-baby dyad. The mean age of participants is 30.69 ± 0.32 years for cases and 29.95 ± 0.32 for controls. Majority (85%) of the participants are between 20-30years. At booking, majority of cases had normal blood pressure compared to the time of diagnosis where 85% had a systolic BP greater than 140mmHg and a corresponding 82% had diastolic pressure greater than 90mmHg. Our study will ultimately provide clinical, biochemical and genotypic data for risk stratification of preeclampsia and careful monitoring during pregnancy to improve clinical management and outcomes.
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影响因子：
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作者：
Shahul S;Tung A;Minhaj M;Nizamuddin J;Wenger J;Mahmood E;Mueller A;Shaefi S;Scavone B;Kociol RD;Talmor D;Rana S
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DOI：
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发表时间：
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期刊：
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影响因子：
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DOI：
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发表时间：
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