Advances in biomarker development and potential application for preeclampsia based on pathogenesis.
Advances in biomarker development and potential application for preeclampsia based on pathogenesis.
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DOI：
10.1016/j.eurox.2020.100119
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发表时间：
2021-01
影响因子：
--
通讯作者：
Wang BS
中科院分区：
文献类型：
--
作者：
Liu N;Guo YN;Gong LK;Wang BS
子痫前期是一种妊娠特有的并发症，严重威胁母婴的健康和安全。PE的病因尚未完全阐明，目前尚无有效的治疗方法。患有PE的孕妇经常不得不在危及自己健康分娩和被迫终止妊娠之间做出艰难选择。国际妇产科联合会建议，母体高危因素和生物标志物的结合可以形成预测PE风险的良好策略。这样的结合还可以在高危人群中进行更有效的监测和早期临床干预，以降低PE的风险。因此，经过广泛临床研究验证的生物标志物可正式应用于临床PE风险预测。在本文中，我们总结了潜在生物标志物的临床研究数据，并根据目前的四个主要假说，即胎盘或滋养细胞缺血缺氧、血管内皮损伤、氧化应激和免疫失调，对其进行了分类。此外，我们还讨论了这些潜在的生物标志物可能参与PE发病的潜在机制。最后，我们建议联合使用反映疾病发病机制不同方面的多种生物标志物来检测高危PE人群，为临床针对性地干预和预防PE提供支持。预计基于上述主要假设进行的更灵敏和可靠的PE生物标志物的测试可能会潜在地提高未来PE预测的准确性。
Preeclampsia (PE) is a pregnancy-specific complication that seriously threatens the health and safety of mothers and infants. The etiology of PE has not been fully elucidated, and no effective treatments are currently available. A pregnant woman with PE often has to make a tough choice on either endangering her own health to give a birth or being forced to terminate her pregnancy. It is recommended by the International Federation of Gynecology and Obstetrics that the combination of maternal high-risk factors and biomarkers could form a good strategy for predicting the risk of PE. Such a combination may also enable more effective monitoring and early clinical intervention in high-risk populations to reduce the risk of PE. Therefore, biomarkers validated by extensive clinical research may be formally applied for clinical PE risk prediction. In this review, we summarized data from clinical research on potential biomarkers and classified them according to the current four major hypotheses, namely placental or trophoblast ischemia and hypoxia, vascular endothelial injury, oxidative stress, and immune dysregulation. Additionally, we also discussed the underlying mechanisms by which these potential biomarkers may be involved in the pathogenesis of PE. Finally, we propose that multiple biomarkers reflecting different aspects of the disease pathogenesis should be used in combination to detect the high-risk PE population in support of clinically targeted intervention and prevention of PE. It is expected that tests made of more sensitive and reliable PE biomarkers based on the aforementioned major hypotheses could potentially improve the accuracy of PE prediction in the future.
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影响因子：
0.7
作者：
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通讯作者：
Radhakrishnan, Gita
影响因子：
2.6
作者：
Ghosh, Sanjib Kumar;Raheja, Shashi;Agarwal, Sneh
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Adank, Maria C.;Benschop, Laura;Steegers, Eric A. P.
通讯作者：
Steegers, Eric A. P.
DOI：
10.1161/hypertensionaha.113.01648
发表时间：
2013-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Brewer J;Liu R;Lu Y;Scott J;Wallace K;Wallukat G;Moseley J;Herse F;Dechend R;Martin JN Jr;Lamarca B
通讯作者：
Lamarca B