Finite element analysis of an accordion-like honeycomb scaffold for cardiac tissue engineering.
Finite element analysis of an accordion-like honeycomb scaffold for cardiac tissue engineering.
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DOI：
10.1016/j.jbiomech.2010.06.032
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发表时间：
2010-11-16
影响因子：
2.4
通讯作者：
Engelmayr, George C., Jr.
中科院分区：
文献类型：
--
作者：
Jean, Aurelie;Engelmayr, George C., Jr.
关键词：
随着适合数学建模的微支架的发展，优化组织工程心肌的功能变得更加可行。在目前的研究中，最近开发的聚甘油癸酸酯（PGS）手风琴状蜂窝（ALH）支架的弹性行为[…]自然材料7(12),1003-1010]。具体来说，利用二维有限元（FE）模型的ALH单元格（周期性边界条件）和细分（运动均匀边界条件）来确定一个代表性的体积单元（RVE），并回顾性地预测弹性有效刚度。发现了90个ALH单位细胞的RVE(≃3:18×4:03mm)，表明以往的单轴试验样品具有一定的力学代表性。对于160℃固化7.5 h的PGS微成形ALH支架，有限元预测的两个正交材料方向（0.081±0.012和0.033±0.005 MPa）的有效刚度与已发表的实验数据（0.083±0.004和0.031±0.002 MPa）的匹配度分别为2.4%和6.4%。模型预测ALH支架的整体应变放大倍数（0.54和0.34）低于矩形蜂窝支架（1.19和0.74），这与之前测量的应变到失效呈负相关。在匹配天然心肌的各向异性力学性能方面，FE预测50μm宽的PGS支架具有最大的各向异性。因此，FE模型将有助于设计ALH孔几何形状的未来变体，同时提供适当的心脏各向异性和降低刚度，以增强心脏细胞介导的收缩性。
Optimizing the function of tissue engineered cardiac muscle is becoming more feasible with the development of microfabricated scaffolds amenable to mathematical modeling. In the current study, the elastic behavior of a recently developed poly(glycerol sebacate) (PGS) accordion-like honeycomb (ALH) scaffold [. Nature Materials 7 (12), 1003–1010] was analyzed. Specifically, 2D finite element (FE) models of the ALH unit cell (periodic boundary conditions) and tessellations (kinematic uniform boundary conditions) were utilized to determine a representative volume element (RVE) and to retrospectively predict the elastic effective stiffnesses. An RVE of 90 ALH unit cells (≃3:18×4:03mm) was found, indicating that previous experimental uni-axial test samples were mechanically representative. For ALH scaffolds microfabricated from PGS cured 7.5 h at 160 1°C, FE predicted effective stiffnesses in the two orthogonal material directions (0.081±0.012 and 0.033±0.005 MPa) matched published experimental data (0.083±0.004 and 0.031±0.002 MPa) within 2.4% and 6.4%. Of potential use as a design criterion, model predicted global strain amplifications were lower in ALH (0.54 and 0.34) versus rectangular honeycomb (1.19 and 0.74) scaffolds, appearing to be inversely correlated with previously measured strains-to-failure. Important in matching the anisotropic mechanical properties of native cardiac muscle, FE predicted ALH scaffolds with 50μm wide PGS struts to be maximally anisotropic. The FE model will thus be useful in designing future variants of the ALH pore geometry that simultaneously provide proper cardiac anisotropy and reduced stiffness to enhance heart cell-mediated contractility.
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影响因子：
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作者：
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通讯作者：
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DOI：
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影响因子：
41.2
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