Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters.
Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters.
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N-亚硝基吡咯烷对雄性叙利亚金仓鼠急性给药的影响。
DOI：
10.1016/0304-3835(94)90255-0
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发表时间：
1994
期刊：
影响因子：
9.7
通讯作者：
Sudilovsky,O
中科院分区：
文献类型：
--
作者：
McCoy,GD;DeMarco,GJ;Haxhiu,L;Roggero,E;Sudilovsky,EC;Sudilovsky,O
A protocol has been developed which decreases the time for administration ofN-nitrosopyrrolidine (NPYR) to male Syrian golden hamsters from 25 weeks to a single i.p. injection. Animals were divided into five groups: group I received two 0.5-mmol doses on alternate days; group II was given three 0.33-mmol doses on alternate days; group III received a single dose of 0.5 mmol; group IV was given a single dose of 0.25 mmol and group V served as a control and received saline. Preneoplastic and neoplastic changes in the upper respiratory tract and liver were observed in all carcinogentreated groups. The number of animals with laryngeal and tracheal tumors in the NPYR-treated groups was dose-dependent. Groups I and II, respectively, had 21 of 26(81%) and 18 or 24 (75%) animals with either laryngeal or tracheal tumors. Groups III and IV showed 4 of 12 (33%) and 3 of 13 (23%) hamsters with these tumors. No laryngeal or tracheal tumors were observed in control animals. These results indicate that a single dose of NPYR is sufficient to induce respiratory tract tumors in Syrian golden hamsters.
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大鼠肝微粒体激活后大肠杆菌中环状亚硝胺的致突变性。
影响因子：
11.2
作者：
R. Elespuru;W. Lijinsky
通讯作者：
W. Lijinsky
叙利亚仓鼠自然发生的肿瘤。
DOI：
10.1159/000401419
发表时间：
1979
期刊：
Progress in experimental tumor research
影响因子：
--
作者：
G. van Hoosier;J. Trentin
通讯作者：
J. Trentin
亚硝胺对呼吸道的器官作用的实验研究。
DOI：
10.1016/0015-6264(68)90293-9
发表时间：
1968
期刊：
Food and cosmetics toxicology
影响因子：
--
作者：
W. Dontenwill
通讯作者：
W. Dontenwill
用 N-亚硝基吡咯烷处理的啮齿动物中 DNA 加合物的形成和持久性。
影响因子：
4.7
作者：
E. J. Hunt;R. C. Shank
通讯作者：
R. C. Shank
慢性乙醇消耗对雄性叙利亚金仓鼠 N-亚硝基吡咯烷致瘤性的影响。
影响因子：
9.7
作者：
McCoy,GD;Hecht,SS;Furuya,K
通讯作者：
Furuya,K