Abnormal target detection and novelty processing neural response in posttraumatic stress disorder.
Abnormal target detection and novelty processing neural response in posttraumatic stress disorder.
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DOI：
10.1016/j.pnpbp.2018.04.003
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发表时间：
2018-07-13
影响因子：
5.6
通讯作者：
Claus ED
中科院分区：
文献类型：
--
作者：
Sanjuan PM;Andrews C;Claus ED
注意力障碍是创伤后应激障碍(PTSD)的常见症状；然而，这些障碍的性质仍然难以捉摸。注意障碍可能是由于对与任务无关的刺激反应过度或对与任务相关的信息反应减少所致。为了测试创伤后应激障碍与对任务相关和任务无关刺激的反应之间的关系，我们使用了一个3音新奇听觉古怪任务(AOD)。我们假设，与创伤对照组相比，患有创伤后应激障碍的受试者在背外侧前额叶皮质(DlPFC)和前扣带回皮质的新颖性加工过程中反应较少，在目标检测过程中dlPFC和眼眶额叶皮质的反应较少。31名男性退伍军人在功能磁共振成像过程中完成了3色调新奇AOD任务。与创伤对照组相比，创伤后应激障碍组在前额叶腹内侧皮层、额上回/额中回、辅助运动区/尾状回以及包括双侧扣带回在内的后方区域的新颖性加工反应降低。目前的结果表明，创伤后应激障碍与对新刺激的反应减少有关。理论上，这些脑区的定向反应紊乱可能是创伤后应激障碍注意力相关症状的基础。
Attention impairments are common symptoms of posttraumatic stress disorder (PTSD); however, the nature of these impairments remains elusive. Attention impairment may arise as the result of either excessive response to task-irrelevant stimuli or reduced response to task-relevant information. To test the association between PTSD and response to task-relevant and task-irrelevant stimuli, we used a 3-tone novelty auditory oddball task (AOD). We hypothesized that participants with PTSD relative to trauma controls would have less response during novelty processing in the dorsolateral prefrontal cortex (dlPFC) and the anterior cingulate cortex, as well as less response in the dlPFC and the orbitofrontal cortex during target detection. Thirty-one male veterans completed a 3-tone novelty AOD task during functional magnetic resonance imaging. Compared to trauma controls, the PTSD group had reduced response during novelty processing in ventromedial prefrontal cortex, superior/middle frontal gyrus (dlPFC), supplementary motor area/caudate, and in posterior regions including bilateral posterior cingulate cortex. The current results suggest PTSD is associated with a pattern of reduced response to novel stimuli. A disturbed orienting response in these brain regions could theoretically underlie PTSD attention-related symptoms.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
10.6
作者：
Kimble, M;Kaloupek, D;Deldin, P
通讯作者：
Deldin, P
DOI：
10.1196/annals.1364.006
发表时间：
2006-01-01
期刊：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS
影响因子：
--
作者：
Golier, Julia A.;Harvey, Philip D.;Yehuda, Rachel
通讯作者：
Yehuda, Rachel
影响因子：
3.7
作者：
Dunkley BT;Sedge PA;Doesburg SM;Grodecki RJ;Jetly R;Shek PN;Taylor MJ;Pang EW
通讯作者：
Pang EW
影响因子：
5.7
作者：
Deichmann, R;Gottfried, JA;Turner, R
通讯作者：
Turner, R