Dilatory and Inotropic Effects of Corticotropin-Releasing Factor (CRF) on the Isolated Heart
Dilatory and Inotropic Effects of Corticotropin-Releasing Factor (CRF) on the Isolated Heart
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促肾上腺皮质激素释放因子 (CRF) 对离体心脏的扩张和正性肌力作用
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
E. Pfeiffer
中科院分区：
文献类型：
--
作者：
M. Grunt;C. Haug;L. Duntas;P. Pauschinger;V. Maier;E. Pfeiffer
观察CRF对大鼠心脏心功能、冠脉流量和心钠素释放的影响。按照工作心脏模型，以恒定充盈压力灌流离体心，灌流液为含葡萄糖和胰岛素的Krebs-Henseleit溶液，饱和气体含95%O2和5%CO2。经导管将CRF注入左心房可引起冠脉流量的持续增加和主动脉压力的一过性增加，从而导致压力-容量功的总体增加。应用CRF后，氧耗量随着心功能的增加而增加。自发性心率无明显变化。此外，CRF可引起冠脉灌流液中ANP释放的短期增加。我们的实验表明，给予CRF对冠状动脉产生持久的扩张作用，同时在离体大鼠心脏上产生一过性正性肌力作用和一过性心钠素释放的增加。
The effects of CRF administration on cardiac performance, coronary flow and ANP release were investigated in the rat heart. Isolated hearts were perfused at a constant filling pressure according to working heart model with a Krebs-Henseleit solution containing glucose and insulin, saturated with a gas mixture containing 95% O2 and 5% CO2. Administration of CRF via a cannula into the left atrium elicited a prolonged increase in the coronary flow rate and a transient increase in the aortic pressure resulting in an overall increase in the pressure-volume work. The oxygen consumption, after the administration of CRF, increased in accordance with the cardiac effort. No changes were observed in the spontaneous heart rate. Furthermore, administration of CRF induced a short-term increase of ANP release into the coronary perfusate. Our experiments suggest that administration of CRF produces a prolonged dilatory effect on the coronary arteries while producing a transient positive inotropic effect and a transient increase of ANP release on the isolated rat heart.
冠状动脉血流动力学和心脏跳动调节离体 Langendorff 灌注大鼠心脏的心房钠尿因子释放。
影响因子：
6.1
作者：
Naruse,M;Higashida,T;Naruse,K;Shibasaki,T;Demura,H;Inagami,T;Shizume,K
通讯作者：
Shizume,K
大鼠心室中心房钠尿因子的合成和存在。
DOI：
10.1016/0006-291x(87)90300-7
发表时间：
1987
影响因子：
3.1
作者：
Takayanagi,R;Imada,T;Inagami,T
通讯作者：
Inagami,T
培养的心肌细胞分泌心房钠尿因子-(99-126) 受糖皮质激素调节。
DOI：
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发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shields,PP;Dixon,JE;Glembotski,CC
通讯作者：
Glembotski,CC