NIRS-Based Study of Local Cerebral Oxygenation During Transcranial Direct Current Stimulation in Patients with Mild Traumatic Brain Injury.
NIRS-Based Study of Local Cerebral Oxygenation During Transcranial Direct Current Stimulation in Patients with Mild Traumatic Brain Injury.
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DOI：
10.1007/978-3-031-14190-4_10
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发表时间：
2022
影响因子：
--
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中科院分区：
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本研究的目的是通过近红外光谱（NIRS）评估经颅直流电刺激（tDCS）在轻度创伤性脑损伤（mTBI）急性期的局部脑氧合（LCO）动态。57例mTBI患者（女性18例，男性39例，年龄（35±11.7）岁，GCS(13.7±0.7)）于颅脑损伤后3 ~ 5 d采用tDCS治疗。刺激参数为：1 mA， 9 V，持续时间-20 min。使用脑血氧仪评估额颞叶lco值。在tDCS前和tDCS结束前每2分钟比较一次正极和正极LCO值。显著性预设为p < 0.05。在刺激第8至12分钟，与阴极侧（第8分钟- p = 0.011；第12分钟- p < 0.00000001）和tDCS前的LCO值相比，观察到阳极侧的LCO值显著下降（p < 0.00001）。在整个tDCS过程中，正极LCO无显著性差异。手术结束时，半球间LCO差异无统计学意义（p = 0.757）。mTBI 3-5天的经颅DCS导致8 - 12分钟阳极侧LCO值显著下降，随后在手术结束时恢复到基线值。
The purpose of our study was to assess the dynamics of local cerebral oxygenation (LCO) by near-infrared spectroscopy (NIRS) during transcranial direct current stimulation (tDCS) in the acute stage of mild traumatic brain injury (mTBI). Fifty-seven mTBI patients (18 women and 39 men, 35 ± 11.7 years old, GCS 13.7 ± 0.7) were treated by tDCS at 3–5 days after head injury. Stimulation parameters were: 1 mA, 9 V, duration-20 min. A cerebral oximeter was used to assess LCO-values in the frontotemporal lobes. Anodal and cathodal LCO values were compared before tDCS and every 2 min until the tDCS end. Significance was preset to p < 0.05. A significant decrease in LCO values on the anodal side was observed at the 8th to 12th minutes of stimulation, compared to the cathodal side (at 8th minute – p = 0.011; at 12th minute – p < 0.00000001) and compared to LCO values before tDCS (p < 0.00001). The LCO on the cathodal side was not significantly different during the whole tDCS. At the end of the procedure, the interhemispheric LCO differences were not statistically significant (p = 0.757). Transcranial DCS in 3–5 days of mTBI leads to a significant decrease in the LCO value on the anodal side between 8 and 12 min and subsequent recovery to baseline values by the end of the procedure.
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影响因子：
1.7
作者：
Stuart, Barbara;Mandleco, Barbara;Heaston, Sondra
通讯作者：
Heaston, Sondra
影响因子：
1.7
作者：
Boissonnault È;Higgins J;LaGarde G;Barthélemy D;Lamarre C;H Dagher J
通讯作者：
H Dagher J
影响因子：
--
作者：
Trofimov AO;Kalentiev G;Karelsky M;Ksenofontova C;Ruzavina A;Yuriev M;Bragin DE
通讯作者：
Bragin DE
影响因子：
2.4
作者：
Zhang, Ke-Ying;Rui, Gang;Ding, Gui-Rong
通讯作者：
Ding, Gui-Rong
DOI：
10.1007/978-3-319-91287-5_5
发表时间：
2018-01-01
期刊：
OXYGEN TRANSPORT TO TISSUE XL
影响因子：
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作者：
Bragina, O. A.;Lara, D. A.;Bragin, D. E.
通讯作者：
Bragin, D. E.