Cerebral Hemodynamics After Transcranial Direct Current Stimulation (tDCS) in Patients with Consequences of Traumatic Brain Injury.
Cerebral Hemodynamics After Transcranial Direct Current Stimulation (tDCS) in Patients with Consequences of Traumatic Brain Injury.
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DOI：
10.1007/978-3-319-91287-5_10
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发表时间：
2018
影响因子：
--
通讯作者：
Bragin DE
中科院分区：
文献类型：
--
作者：
Trofimov AO;Kalentiev G;Karelsky M;Ksenofontova C;Ruzavina A;Yuriev M;Bragin DE
近年来，希望更好地治疗创伤性脑损伤（TBI）集中在非药物经颅电脑刺激，然而，刺激后的灌注变化的研究很少和矛盾。因此，本研究的目的是评估创伤后脑病（PTE）患者接受高清经颅直流电刺激（HD-tDCS）后的脑灌注。20例PTE患者（16例男性和4例女性，年龄35.5 ± 14.8岁）接受了灌注计算机断层扫描（PCT），随后在TBI后21天接受了阳极HD-tDCS和刺激后断层扫描。建立Westermark灌注图并计算定量灌注参数。显著性预设为P < 0.05。定性分析显示，所有患者的脑血流量（CBF）减少，平均平均通过时间（MTT）增加的领域。HD-tDCS伴随着低灌注和缺血区的数量显著减少（p < 0.05）。定量分析显示，在所有患者中，HD-tDCS导致阳极侧额颞区CBF（p < 0.001）、脑血容量（CBV）（p< 0.01）和MTT缩短（p < 0.05）显著增加。在基底神经节中，仅在5名最初降低（p < 0.01）且仅在同侧放置阳极的患者中发现CBF显著增加。在PTE TBI并发症患者中，HD-tDCS导致CBV、CBF显著增加，平均MTT降低，表明组织氧输送更好。
In recent years, hopes for better treatment of traumatic brain injury (TBI) have focused on non-pharmacologic transcranial electrical brain stimulation; however, studies of perfusion changes after stimulation are few and contradictory. Therefore, the aim of this study was to assess cerebral perfusion after high-definition transcranial direct current stimulation (HD-tDCS) in patients with posttraumatic encephalopathy (PTE). Twenty patients with PTE (16 men and 4 women, aged 35.5 ± 14.8 years) underwent perfusion computed tomography (PCT), followed by anodal HD-tDCS and post-stimulation tomography at 21 days after TBI. The Westermark perfusion maps were constructed and quantitative per-fusion parameters calculated. Significance was preset to P < 0.05. Qualitative analysis revealed that all patients had areas with reduced cerebral blood flow (CBF) and increased average mean transit time (MTT). HD-tDCS was accompanied by a significant decrease in the number of zones of both hypoperfusion and ischemia (p < 0.05). Quantitative analysis showed that, in all patients, HD-tDCS caused a significant increase in CBF (p < 0.001), cerebral blood volume (CBV) (p< 0.01) and MTT shortening (p < 0.05) in the frontotemporal region on the anode side. In the basal ganglia, a significant increase in CBF was found only in the 5 patients in whom this was initially reduced (p < 0.01) and only with an anode placed on the same side. In patients with complications due to PTE TBI, HD-tDCS causes a significant increase in CBV, CBF and a decrease in the average MTT, suggesting better oxygen delivery to tissue.
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影响因子：
16.6
作者：
Monai H;Ohkura M;Tanaka M;Oe Y;Konno A;Hirai H;Mikoshiba K;Itohara S;Nakai J;Iwai Y;Hirase H
通讯作者：
Hirase H
影响因子：
4.1
作者：
Hlatky, Roman;Valadka, Alex B.;Robertson, Claudia S.
通讯作者：
Robertson, Claudia S.
影响因子：
2.6
作者：
Long, Haiyan;Yang, Gang;Wang, Zhengrong
通讯作者：
Wang, Zhengrong
影响因子：
4.2
作者：
Palzur, E;Vlodavsky, E;Soustiel, JF
通讯作者：
Soustiel, JF
影响因子：
5.5
作者：
Nitsche, MA;Paulus, W
通讯作者：
Paulus, W