Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences.
Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences.
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DOI：
10.1038/s42003-021-02140-y
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发表时间：
2021-06-03
影响因子：
5.9
通讯作者：
Tewari AK
中科院分区：
文献类型：
--
作者：
Rayford W;Beksac AT;Alger J;Alshalalfa M;Ahmed M;Khan I;Falagario UG;Liu Y;Davicioni E;Spratt DE;Schaeffer EM;Feng FY;Mahal B;Nguyen PL;Den RB;Greenberger MD;Bradley R;Watson JM;Beamer M;Stamatakis L;Carmen DJ;Awasthi S;Hwang J;Weil R;Merisaari H;Mohamed N;Deane LA;Chakravarty D;Yadav KK;Yamoah K;Nair SS;Tewari AK
前列腺癌的种族差异在基因组水平上还没有得到很好的表征。在这里，我们展示了对接受根治性前列腺切除术的1152名患者(596名非洲裔美国人(AAM)和556名欧洲裔美国人(EAM))进行多机构回顾分析的结果。在临床、基因组、途径、分子亚型和预后水平上进行种族组间的比较分析。EAM组ERG(P <； 0.001)和Ets(P = 0.02)表达增加，SPINK1表达降低(P <； 0.001)和碱基样样(P <； 0.001)分子亚型。在调整混杂因素后，AAM组CRYBB2、GSTM3和炎症基因(IL33、IFNG、CCL4、CD3、ICOSLG)的表达较高，而错配修复基因(Msh2、Msh6)的表达较低(p <； 0.001)。在通路水平上，AAM组与免疫反应、细胞凋亡、低氧和活性氧相关的基因集表达水平较高。EAM组的脂肪酸代谢、DNA修复和WNT/β-连环蛋白信号水平较高。根据细胞系数据，预测AAM对DNA损伤有更高的潜在反应。综上所述，AAM与EAM相比，前列腺癌的生物学特性有很大的不同。沃尔特·雷福德，ALP金枪鱼Beksac等人。调查了接受前列腺癌根治术的非裔美国人和欧洲裔美国人的基因表达变化。观察到的差异包括非洲裔美国人中炎症基因的表达较高，错配修复基因的表达较低。
Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P < 0.001) and ETS (P = 0.02) expression, decreased SPINK1 expression (P < 0.001), and basal-like (P < 0.001) molecular subtypes. After adjusting for confounders, the AAM group was associated with higher expression of CRYBB2, GSTM3, and inflammation genes (IL33, IFNG, CCL4, CD3, ICOSLG), and lower expression of mismatch repair genes (MSH2, MSH6) (p < 0.001 for all). At the pathway level, the AAM group had higher expression of genes sets related to the immune response, apoptosis, hypoxia, and reactive oxygen species. EAM group was associated with higher levels of fatty acid metabolism, DNA repair, and WNT/beta-catenin signaling. Based on cell lines data, AAM were predicted to have higher potential response to DNA damage. In conclusion, biological characteristics of prostate tumor were substantially different in AAM when compared to EAM. Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
前列腺癌的种族差异：分子视角。
DOI：
10.2741/4515
发表时间：
2017-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Bhardwaj A;Srivastava SK;Khan MA;Prajapati VK;Singh S;Carter JE;Singh AP
通讯作者：
Singh AP
影响因子：
16
作者：
Nair, Sujit S.;Li, Da-Qiang;Kumar, Rakesh
通讯作者：
Kumar, Rakesh
DOI：
10.1007/s00520-015-2706-9
发表时间：
2015-11
期刊：
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
影响因子：
--
作者：
Palmer NR;Weaver KE;Hauser SP;Lawrence JA;Talton J;Case LD;Geiger AM
通讯作者：
Geiger AM
影响因子：
4.8
作者：
Den, R. B.;Santiago-Jimenez, M.;Shah, N. L.
通讯作者：
Shah, N. L.