Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa.
Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa.
复制标题
DOI：
10.1371/journal.pone.0090681
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Koyano K
中科院分区：
文献类型：
--
作者：
Kondo R;Atsuta I;Ayukawa Y;Yamaza T;Matsuura Y;Furuhashi A;Tsukiyama Y;Koyano K
本研究的目的是探讨系统移植的间充质干细胞(MSCs)对种植体周围上皮封闭的影响。从供体大鼠骨髓中分离、扩增骨髓间充质干细胞。受体大鼠拔除上颌右第一磨牙后，在骨槽内植入实验性钛种植体，将供体大鼠骨髓间充质干细胞静脉移植到受体大鼠体内。移植后24小时，植入的MSCs在种植体周围的口腔粘膜内可见。在种植后早期，MSC移植加速了种植体周围上皮(PIE)介导的黏膜封闭的形成。随后，在替换后4周，发现层粘连蛋白-332在PIE-种植体界面上沉积增强。我们还观察到口腔粘膜上皮细胞的附着和增殖增强。系统移植的MSCs可能在加强种植体周围的上皮封闭方面发挥关键作用。
The objective of this study was to investigate the effect of systemically transplanted mesenchymal stem cells (MSCs) on the peri-implant epithelial sealing around dental implants. MSCs were isolated from bone marrow of donor rats and expanded in culture. After recipient rats received experimental titanium dental implants in the bone sockets after extraction of maxillary right first molars, donor rat MSCs were intravenously transplanted into the recipient rats. The injected MSCs were found in the oral mucosa surrounding the dental implants at 24 hours post-transplantation. MSC transplantation accelerated the formation of the peri-implant epithelium (PIE)-mediated mucosa sealing around the implants at an early stage after implantation. Subsequently, enhanced deposition of laminin-332 was found along the PIE-implant interface at 4 weeks after the replacement. We also observed enhanced attachment and proliferation of oral mucous epithelial cells. Systemically transplanted MSCs might play a critical role in reinforcing the epithelial sealing around dental implants.
登录
查看更多内容
影响因子：
20.3
作者：
Lee, OK;Kuo, TK;Chen, TH
通讯作者：
Chen, TH
影响因子：
14
作者：
Atsuta, I;Yamaza, T;Tanaka, T
通讯作者：
Tanaka, T
影响因子：
4.3
作者：
Esposito, M;Thomsen, P;Lekholm, U
通讯作者：
Lekholm, U
影响因子：
168.9
作者：
LeBlanc, Katarina;Frassoni, Francesco;Ringden, Olle
通讯作者：
Ringden, Olle
影响因子：
3.9
作者：
García-Olmo, D;García-Arranz, M;Rodríguez-Montes, JA
通讯作者：
Rodríguez-Montes, JA