Olivocochlear Changes Associated With Aging Predominantly Affect the Medial Olivocochlear System.
Olivocochlear Changes Associated With Aging Predominantly Affect the Medial Olivocochlear System.
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DOI：
10.3389/fnins.2021.704805
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发表时间：
2021
影响因子：
4.3
通讯作者：
Lauer AM
中科院分区：
文献类型：
--
作者：
Vicencio-Jimenez S;Weinberg MM;Bucci-Mansilla G;Lauer AM
听力损失（ARHL）是一个公共卫生问题，与从虚弱增加到痴呆症风险增加的负面健康结果有关。在我们对潜在的中枢神经机制的认识中仍然存在重大差距，特别是那些与传出听觉通路相关的机制。因此，本研究的目的是量化和比较年龄相关的胆碱能橄榄耳蜗传出听觉神经元的变化。我们评估，在10-成年和老年CBA小鼠，胆碱能olivoclear神经元的数量，听觉脑干反应（ABR）阈值在沉默和背景噪声的存在下，和兴奋性和抑制性蛋白的表达在腹侧核的斜方体（VNTB）和外侧上级橄榄（LSO）。在与老化，我们发现了一个显着的减少内侧橄榄耳蜗（MOC）胆碱能神经元的数量与变化的兴奋性和抑制性蛋白的VNTB的比例。此外，在老年小鼠中，我们确定了在背景噪声存在下MOC神经元的数量和ABR阈值之间的相关性。相比之下，在外侧橄榄耳蜗系统中观察到的改变不太显著。与衰老相关的海马神经元数量的减少是MOC的2.7倍，并且在LSO中兴奋性和抑制性蛋白表达没有变化的情况下。这些差异表明，老化改变了内侧和外侧橄榄耳蜗传出通路的差异的方式，观察到的变化可能会解释一些ARHL中看到的症状。
Age-related hearing loss (ARHL) is a public health problem that has been associated with negative health outcomes ranging from increased frailty to an elevated risk of developing dementia. Significant gaps remain in our knowledge of the underlying central neural mechanisms, especially those related to the efferent auditory pathways. Thus, the aim of this study was to quantify and compare age-related alterations in the cholinergic olivocochlear efferent auditory neurons. We assessed, in young-adult and aged CBA mice, the number of cholinergic olivocochlear neurons, auditory brainstem response (ABR) thresholds in silence and in presence of background noise, and the expression of excitatory and inhibitory proteins in the ventral nucleus of the trapezoid body (VNTB) and in the lateral superior olive (LSO). In association with aging, we found a significant decrease in the number of medial olivocochlear (MOC) cholinergic neurons together with changes in the ratio of excitatory and inhibitory proteins in the VNTB. Furthermore, in old mice we identified a correlation between the number of MOC neurons and ABR thresholds in the presence of background noise. In contrast, the alterations observed in the lateral olivocochlear (LOC) system were less significant. The decrease in the number of LOC cells associated with aging was 2.7-fold lower than in MOC and in the absence of changes in the expression of excitatory and inhibitory proteins in the LSO. These differences suggest that aging alters the medial and lateral olivocochlear efferent pathways in a differential manner and that the changes observed may account for some of the symptoms seen in ARHL.
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影响因子：
16.6
作者：
Corns LF;Johnson SL;Roberts T;Ranatunga KM;Hendry A;Ceriani F;Safieddine S;Steel KP;Forge A;Petit C;Furness DN;Kros CJ;Marcotti W
通讯作者：
Marcotti W
影响因子：
56.9
作者：
BUCHWALD, JS;HUANG, CM
通讯作者：
HUANG, CM
影响因子：
--
作者：
ABERCROMBIE, M
通讯作者：
ABERCROMBIE, M
DOI：
10.1682/jrrd.2005.01.0006
发表时间：
2005-07-01
影响因子：
--
作者：
Gordon-Salant, S
通讯作者：
Gordon-Salant, S
DOI：
10.1073/pnas.2000760117
发表时间：
2020-05-26
影响因子：
11.1
作者：
Boero, Luis E.;Castagna, Valeria C.;Eugenia Gomez-Casati, Maria
通讯作者：
Eugenia Gomez-Casati, Maria