Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.
Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.
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DOI：
10.1038/s41467-018-06307-w
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发表时间：
2018-10-01
影响因子：
16.6
通讯作者：
Marcotti W
中科院分区：
文献类型：
--
作者：
Corns LF;Johnson SL;Roberts T;Ranatunga KM;Hendry A;Ceriani F;Safieddine S;Steel KP;Forge A;Petit C;Furness DN;Kros CJ;Marcotti W
在成人听觉器官中，机械电换能器（MET）通道是将声刺激转换为电信号的关键。在没有传入声音的情况下，感觉毛细胞顶部的一部分MET通道打开，导致持续的去极化电流。通过遗传操纵MET装置的分子组分的体内表达，我们表明，在听前阶段的MET电流是必不可少的建立成熟的内毛细胞（IHC）的电生理特性。如果MET电流在成人IHC中被废除，它们将恢复为显示听觉前IHC的电和形态特征的细胞，包括胆碱能传出神经支配的重建。因此，MET电流对于维持成人IHC的功能特性是至关重要的，这意味着成熟听觉系统响应于声信号的正常转导的缺乏而具有一定程度的可塑性。内毛细胞尖端的机械电转换器（MET）通道是传导听觉感觉信息所必需的。在这里，作者表明，破坏MET通道功能也会阻止成年小鼠正常内毛细胞身份的保留。
In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). If the MET current is abolished in adult IHCs, they revert into cells showing electrical and morphological features characteristic of pre-hearing IHCs, including the re-establishment of cholinergic efferent innervation. The MET current is thus critical for the maintenance of the functional properties of adult IHCs, implying a degree of plasticity in the mature auditory system in response to the absence of normal transduction of acoustic signals. Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice.
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毛细胞的机械感觉结构需要 clarin-1，这是一种由 Usher 综合征 III 致病基因编码的蛋白质。
DOI：
10.1523/jneurosci.0311-12.2012
发表时间：
2012-07-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Geng R;Melki S;Chen DH;Tian G;Furness DN;Oshima-Takago T;Neef J;Moser T;Askew C;Horwitz G;Holt JR;Imanishi Y;Alagramam KN
通讯作者：
Alagramam KN
影响因子：
25
作者：
Gregory FD;Bryan KE;Pangršič T;Calin-Jageman IE;Moser T;Lee A
通讯作者：
Lee A
影响因子：
16.2
作者：
Clause A;Kim G;Sonntag M;Weisz CJ;Vetter DE;Rűbsamen R;Kandler K
通讯作者：
Kandler K
影响因子：
5.3
作者：
Furness, David N.;Mahendrasingam, Shanthini;Hackney, Carole M.
通讯作者：
Hackney, Carole M.
影响因子：
64.8
作者：
BOSHER, SK;WARREN, RL
通讯作者：
WARREN, RL