Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
Immunoglobulin G glycome composition in transition from premenopause to postmenopause.
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从绝经前到绝经后过渡期的免疫球蛋白G糖组组成。
DOI：
10.1016/j.isci.2022.103897
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发表时间：
2022-03-18
期刊：
影响因子：
5.8
通讯作者：
Lauc G
中科院分区：
文献类型：
--
作者：
Deriš H;Kifer D;Cindrić A;Petrović T;Cvetko A;Trbojević-Akmačić I;Kolčić I;Polašek O;Newson L;Spector T;Menni C;Lauc G
性腺激素影响免疫球蛋白G（IgG）的糖基化，而更多的促炎IgG糖组组成可能是围绝经期促炎表型增加背后的分子机制之一。使用超高效液相色谱法，我们分析了来自1940名绝经前、绝经后和绝经后妇女的5,080份样本中的IgG糖组组成。在绝经后女性中观察到半乳糖基化和唾液酸化的统计学显著性降低。此外，在从绝经前到绝经后的过渡期，无半乳糖基化结构的增加速率（0.051/年; 95%CI = 0.043-0.059，p < 0.001）和双半乳糖基化（-0.043/年; 95%CI =-0.050至-0.037，p < 0.001）和单唾液酸化聚糖（-0.029/年; 95%CI =-0.034至-0.024，p < 0.001）显着高于绝经前或绝经后时期。转化为更促炎的IgG糖组和由此导致的IgG抑制低度慢性炎症的能力降低可能是介导围绝经期和绝经后健康风险增加的重要分子机制。绝经前和绝经后女性和男性中IgG N-聚糖的不同水平围绝经期导致无半乳糖基化聚糖结构的增加率更高围绝经期导致双半乳糖基化和单唾液酸化聚糖的更快减少促炎性IgG糖组可能介导围绝经期健康风险的增加生殖医学;分子生物学;糖组学;
Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause. Using ultra-high-performance liquid chromatography, we analyzed IgG glycome composition in 5,080 samples from 1940 pre-, peri-, and postmenopausal women. Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women. Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr; 95%CI = 0.043–0.059, p < 0.001) and decrease in digalactosylated (−0.043/yr; 95%CI = −0.050 to −0.037, p < 0.001) and monosialylated glycans (−0.029/yr; 95%CI = −0.034 to −0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods. The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause. Different levels of IgG N-glycans in premenopausal and postmenopausal women and men Perimenopause causes a higher rate of increase in agalactosylated glycan structures Perimenopause causes faster decrease of digalactosylated and monosialylated glycans Proinflammatory IgG glycome may mediate the increased health risk in perimenopause Reproductive medicine; Molecular biology; Glycomics;
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影响因子：
82.9
作者：
Karsten, Christian M.;Pandey, Manoj K.;Figge, Julia;Kilchenstein, Regina;Taylor, Philip R.;Rosas, Marcela;McDonald, Jacqueline U.;Orr, Selinda J.;Berger, Markus;Petzold, Dominique;Blanchard, Veronique;Winkler, Andre;Hess, Constanze;Reid, Delyth M.;Majoul, Irina V.;Strait, Richard T.;Harris, Nathaniel L.;Koehl, Gabriele;Wex, Eva;Ludwig, Ralf;Zillikens, Detlef;Nimmerjahn, Falk;Finkelman, Fred D.;Brown, Gordon D.;Ehlers, Marc;Koehl, Joerg
通讯作者：
Koehl, Joerg
影响因子：
3.5
作者：
De Martinis, M;Franceschi, C;Ginaldi, L
通讯作者：
Ginaldi, L
影响因子：
5.3
作者：
Franceschi, Claudio;Capri, Miriam;Salvioli, Stefano
通讯作者：
Salvioli, Stefano
影响因子：
14.8
作者：
Kristic, Jasminka;Zaytseva, Olga O.;Lauc, Gordan
通讯作者：
Lauc, Gordan
影响因子：
4.9
作者：
Kifer D;Louca P;Cvetko A;Deriš H;Cindrić A;Grallert H;Peters A;Polašek O;Gornik O;Mangino M;Spector TD;Valdes AM;Padmanabhan S;Gieger C;Lauc G;Menni C
通讯作者：
Menni C