A study of longitudinal tumor motion in helical tomotherapy using a cylindrical phantom.

A study of longitudinal tumor motion in helical tomotherapy using a cylindrical phantom.
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DOI:
10.1120/jacmp.v14i2.4022
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发表时间:
2013-03-04
影响因子:
2.1
通讯作者:
Yartsev S
Yartsev S
中科院分区:
医学4区
文献类型:
--
作者:
Klein M;Gaede S;Yartsev S

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由于多叶准直器的运动、机架旋转以及通过机架的患者床平移的相互作用,螺旋断层放射治疗期间的肿瘤运动可能会产生问题。本研究使用放置在呼吸运动平台上的由 1386 个二极管探测器组成的圆柱形模型评估了典型临床参数的相互作用效应。辐射野宽度(1、2.5 和 5 厘米)和机架旋转周期(16、30 和 60 秒)的所有组合都被考虑用于周期为 4 秒、幅度为 5、6、7、8、9 和 10 毫米的正弦运动,以及真实的患者呼吸模式。使用 2% 剂量差异和 2 毫米距离一致性的伽玛比较和剂量分布进行评估。确定每组参数所需的运动裕度。所需的边缘尺寸随着视野宽度的减小和肿瘤运动幅度的增加而增加,但不受旋转周期的影响。最小场宽为 1 cm 的计划所需的运动裕度约等于运动幅度 (),而最大场宽为 5 cm 的计划所需的运动裕度约等于运动幅度的 20% ()。对于低于 6 毫米的肿瘤运动幅度和高于 1 厘米的视野宽度,所需的额外运动裕度非常小,正弦呼吸模式最大为 2.5 毫米,真实患者呼吸模式最大为 1.2 毫米。 PACS 号码:87.55.km、87.55.Qr、87.56.Fc
Tumor motion during radiation treatment on a helical tomotherapy unit may create problems due to interplay with motion of the multileaf collimator, gantry rotation, and patient couch translation through the gantry. This study evaluated this interplay effect for typical clinical parameters using a cylindrical phantom consisting of 1386 diode detectors placed on a respiratory motion platform. All combinations of radiation field widths (1, 2.5, and 5 cm) and gantry rotation periods (16, 30, and 60 s) were considered for sinusoidal motions with a period of 4 s and amplitudes of 5, 6, 7, 8, 9, and 10 mm, as well as real patient breathing pattern. Gamma comparisons with 2% dose difference and 2 mm distance to agreement and dose profiles were used for evaluation. The required motion margins were determined for each set of parameters. The required margin size increased with decreasing field width and increasing tumor motion amplitude, but was not affected by rotation period. The plans with the smallest field width of 1 cm have required motion margins approximately equal to the amplitude of motion (), while those with the largest field width of 5 cm had required motion margins approximately equal to 20% of the motion amplitude (). For tumor motion amplitudes below 6 mm and field widths above 1 cm, the required additional motion margins were very small, at a maximum of 2.5 mm for sinusoidal breathing patterns and 1.2 mm for the real patient breathing pattern. PACS numbers: 87.55.km, 87.55.Qr, 87.56.Fc
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