Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
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DOI：
10.2337/dc12-0336
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发表时间：
2012-11
期刊：
影响因子：
16.2
通讯作者：
Giugliano D
中科院分区：
文献类型：
--
作者：
Esposito K;Chiodini P;Colao A;Lenzi A;Giugliano D
现有证据支持代谢综合征可能与某些常见癌症风险相关的新假说。我们做了一个系统的回顾和荟萃分析，以评估代谢综合征和不同部位癌症风险之间的关联。我们对截至2011年10月发表的文章进行了电子检索，没有限制，并通过审查检索文章的参考文献列表。每项纳入研究均报告代谢综合征与癌症之间相关性的风险估计值（95%CI）。我们分析了来自43篇文章的116个数据集，包括38，940例癌症病例。在男性队列研究中，代谢综合征的存在与肝癌（相对危险度1.43，P < 0.0001）、结直肠癌（1.25，P < 0.001）和膀胱癌（1.10，P = 0.013）相关。在女性队列研究中，代谢综合征的存在与子宫内膜癌（1.61，P = 0.001）、胰腺癌（1.58，P < 0.0001）、绝经后乳腺癌（1.56，P = 0.017）、直肠癌（1.52，P = 0.005）和结直肠癌（1.34，P = 0.006）相关。女性胰腺癌（P = 0.01）和直肠癌（P = 0.01）与代谢综合征的相关性强于男性。不同种族之间的相关性不同：我们记录了亚洲人群与肝癌（P = 0.002），欧洲人群与女性结直肠癌（P = 0.004）和美国人群（白人）与前列腺癌（P = 0.001）的更强关联。代谢综合征与常见癌症的风险增加有关;对于某些癌症，风险在性别，人群和代谢综合征的定义之间存在差异。
Available evidence supports the emerging hypothesis that metabolic syndrome may be associated with the risk of some common cancers. We did a systematic review and meta-analysis to assess the association between metabolic syndrome and risk of cancer at different sites. We conducted an electronic search for articles published through October 2011 without restrictions and by reviewing reference lists from retrieved articles. Every included study was to report risk estimates with 95% CIs for the association between metabolic syndrome and cancer. We analyzed 116 datasets from 43 articles, including 38,940 cases of cancer. In cohort studies in men, the presence of metabolic syndrome was associated with liver (relative risk 1.43, P < 0.0001), colorectal (1.25, P < 0.001), and bladder cancer (1.10, P = 0.013). In cohort studies in women, the presence of metabolic syndrome was associated with endometrial (1.61, P = 0.001), pancreatic (1.58, P < 0.0001), breast postmenopausal (1.56, P = 0.017), rectal (1.52, P = 0.005), and colorectal (1.34, P = 0.006) cancers. Associations with metabolic syndrome were stronger in women than in men for pancreatic (P = 0.01) and rectal (P = 0.01) cancers. Associations were different between ethnic groups: we recorded stronger associations in Asia populations for liver cancer (P = 0.002), in European populations for colorectal cancer in women (P = 0.004), and in U.S. populations (whites) for prostate cancer (P = 0.001). Metabolic syndrome is associated with increased risk of common cancers; for some cancers, the risk differs betweens sexes, populations, and definitions of metabolic syndrome.
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DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
DOI：
10.1158/1055-9965.epi-09-0235
发表时间：
2009-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kabat GC;Kim M;Chlebowski RT;Khandekar J;Ko MG;McTiernan A;Neuhouser ML;Parker DR;Shikany JM;Stefanick ML;Thomson CA;Rohan TE
通讯作者：
Rohan TE
影响因子：
24
作者：
Jafri, Haseeb;Alsheikh-Ali, Alawi A.;Karas, Richard H.
通讯作者：
Karas, Richard H.
影响因子：
2.8
作者：
De Nunzio, Cosimo;Freedland, Stephen J.;Tubaro, Andrea
通讯作者：
Tubaro, Andrea
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.