SENP1 is required for the growth, migration, and survival of human adipose-derived stem cells.
SENP1 is required for the growth, migration, and survival of human adipose-derived stem cells.
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SENP1 是人类脂肪干细胞生长、迁移和存活所必需的
DOI：
10.1080/21623945.2020.1863625
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发表时间：
2021-12
期刊：
影响因子：
3.3
通讯作者：
Wang M
中科院分区：
文献类型：
--
作者：
Wu Y;Yu B;Wang M
人脂肪来源干细胞(HADSCs)是一种成体间充质细胞，由于其易于获取和扩增、细胞培养丰富、增殖率高、衰老慢等优点，引起了临床科学家和外科医生的广泛关注。SUMO/SENTRIN特异性蛋白水解酶1(SENP1)是SUMO和DESUMO过程中所需的一种关键的蛋白水解酶，是影响细胞周期进程、细胞增殖和细胞凋亡状态的动态机制。然而，SENP1在hADSCs的这些重要细胞过程中的作用在很大程度上还不清楚，还需要在这一领域进行进一步的研究。在这里，我们首次表明，在hADSCs中敲除SENP1后，它们的迁移和增殖能力受到抑制，而凋亡得到增强。然而，SENP1对hADSCs的形态和MSC相关表型没有显著影响。这些结果突出了SENP1在hADSC生长过程中的作用，以及它作为治疗靶点在临床上提高hADSC的有效性和安全性的潜力。
Human adipose-derived stem cells (hADSCs) are adult mesenchymal cells that have attracted the interest of clinical scientists and surgeons due to their large number of advantages including ease of access and expansion, abundance in cell culture, high proliferative rates, and lower senescence. SUMO/sentrin specific protease 1 (SENP1) is a critical protease that is required during the process of SUMOylation and deSUMOylation, which are dynamic mechanisms that influence cell cycle progression, cell proliferation, and apoptotic status. However, the contribution of SENP1 to these important cellular processes in hADSCs is largely uncharacterized and further studies in this area are required. Here, we show for the first time that after knock out SENP1 in hADSCs, their capacity to migrate and proliferate were inhibited, while apoptosis was enhanced. However, SENP1 did not significantly influence the morphology and MSC-related phenotypes of the hADSCs. These results highlight a role for SENP1 during hADSC growth, and its potential as a therapeutic target to improve the efficacy and safety of hADSCs in the clinic.
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影响因子：
4.8
作者：
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DOI：
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