Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine.
Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine.
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DOI：
10.1177/0022034509340867
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发表时间：
2009-09
影响因子：
7.6
通讯作者：
Shi S
中科院分区：
文献类型：
--
作者：
Huang GT;Gronthos S;Shi S
到目前为止，已分离和鉴定了5种不同的人牙髓干/祖细胞：牙髓干细胞(DPSCS)、脱落乳牙干细胞(SHEAD)、牙周膜干细胞(PDLSCs)、根尖乳头干细胞(SCAP)和牙囊前体细胞(DFPC)。这些出生后的群体具有间充质干细胞样(MSC)特性，包括自我更新能力和多系分化潜能。骨髓间充质干细胞(BMMSCs)具有向成骨细胞、软骨细胞、脂肪细胞、肌细胞和神经细胞等多种细胞分化的能力。牙齿组织来源的干细胞是从具有强大分化能力的特殊组织中分离出来的，可以分化为牙源性细胞。然而，它们也有能力产生其他类似于BMMSCs的细胞谱系，但在效力上与BMMSCs不同。本文将对不同牙科MSC样细胞的分离和特性进行综述，并与其他MSCs(如BMMSCs)进行比较。还将讨论干细胞生物学中的重要问题，如干细胞的定位、归巢和免疫调节。
To date, 5 different human dental stem/progenitor cells have been isolated and characterized: dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAP), and dental follicle progenitor cells (DFPCs). These post-natal populations have mesenchymal-stem-cell-like (MSC) qualities, including the capacity for self-renewal and multilineage differentiation potential. MSCs derived from bone marrow (BMMSCs) are capable of giving rise to various lineages of cells, such as osteogenic, chondrogenic, adipogenic, myogenic, and neurogenic cells. The dental-tissue-derived stem cells are isolated from specialized tissue with potent capacities to differentiate into odontogenic cells. However, they also have the ability to give rise to other cell lineages similar to, but different in potency from, that of BMMSCs. This article will review the isolation and characterization of the properties of different dental MSC-like populations in comparison with those of other MSCs, such as BMMSCs. Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed.
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影响因子：
0.9
作者：
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通讯作者：
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作者：
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