Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.
Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.
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DOI：
10.1007/s00018-021-03885-9
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Adameyko I
中科院分区：
文献类型：
--
作者：
Kaucka M;Szarowska B;Kavkova M;Kastriti ME;Kameneva P;Schmidt I;Peskova L;Joven Araus A;Simon A;Kaiser J;Adameyko I
黑素细胞是色素细胞，主要存在于脊椎动物的皮肤和毛囊中，它们有助于着色和抵御 UV-B 辐射。然而，它们的功能范围远远不止于此。例如，这些产生色素的细胞存在于内耳内部，它们有助于听力功能；也存在于心脏中，它们参与导电性并支持心脏瓣膜的硬度。这种皮外黑素细胞的胚胎起源尚不清楚。我们利用谱系追踪实验结合 3D 可视化和基因敲除策略来解决这个长期存在的问题。我们发现，施万细胞前体是在胚胎发育过程中从局部神经支配中招募出来的，并在心脏、脑膜、内耳和其他部位产生皮外黑素细胞。在敲除 EdnrB 受体（一种模仿瓦登堡综合征的病症）的胚胎中，我们只观察到与神经相关的黑素细胞，它们无法从神经上分离并进入内耳。最后，我们研究了皮外黑素细胞的进化方面，发现色素细胞主要与两栖动物和鱼类的神经和血管有关。这种关于皮外色素细胞神经依赖性起源的新知识可能与人类皮外黑色素瘤的形成直接相关。在线版本包含可在 10.1007/s00018-021-03885-9 获取的补充材料。
Melanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans. The online version contains supplementary material available at 10.1007/s00018-021-03885-9.
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影响因子：
4.3
作者：
Bergeron KF;Nguyen CM;Cardinal T;Charrier B;Silversides DW;Pilon N
通讯作者：
Pilon N
影响因子：
64.5
作者：
Adameyko, Igor;Lallemend, Francois;Ernfors, Patrik
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Ernfors, Patrik
影响因子：
2.8
作者：
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Arvanitis, Leonidas D.
DOI：
10.1002/ar.21524
发表时间：
2012-02-01
影响因子：
2
作者：
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通讯作者：
De Oliveira, Classius
影响因子：
1.5
作者：
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通讯作者：
Epstein, Miles L.