Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus.
Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus.
复制标题
2型糖尿病患者颈动脉粥样硬化及其与冠心病和脑卒中风险的关系
DOI：
10.1097/md.0000000000008151
复制
发表时间：
2017-09
期刊：
影响因子：
1.6
通讯作者：
Shan PF
中科院分区：
文献类型：
--
作者：
Wu Y;He J;Sun X;Zhao YM;Lou HY;Ji XL;Pang XH;Shan LZ;Kang YX;Xu J;Zhang SZ;Wang YJ;Ren YZ;Shan PF
颈动脉粥样硬化（CA）和颈动脉斑块（CP）与心血管疾病密切相关。本研究旨在确定2型糖尿病（T2 DM）患者中CA和CP的患病率及其与10年卒中和冠心病（CHD）风险的关系。我们研究了1584例20岁及以上的T2 DM患者。超声检测CA和CP。使用英国前瞻性糖尿病研究（UKPDS）风险引擎确定10年卒中和CHD风险。CA和CP的患病率随着年龄的增长而逐渐增加。男性CA患病率高于女性（CA：58.18%比51.54%，P <.01）。 CA患者10年CHD危险性（27.9%vs15.4%，P <0.001）和卒中危险性（15.2%vs5.70%，P <0.001）均高于非CA患者。 与非CA患者相比，CA和CP组中CHD的OR值分别为男性4.47和10.78，女性4.19和5.20;在卒中病例中，CA和CP组中男性OR值分别为8.83和12.07，女性OR值分别为4.35和4.90（均P<0.001）。 多因素Logistic回归分析显示CA是冠心病和脑卒中的独立危险因素[OR = 2.66，95%CI（2.05-3.46），P <.001]，OR = 3.11，95%CI（2.38-4.07），P <.001。 CA和CP在T2 DM患者中普遍存在，并与10年CHD和卒中风险呈正相关。CA是10年CHD风险的独立危险因素。
Abstract Carotid atherosclerosis (CA) and carotid plaque (CP) are highly correlated with cardiovascular disease. We aimed to determine the prevalence of CA and CP and their relationship with 10-year risks of stroke and coronary heart disease (CHD) in type 2 diabetes mellitus (T2DM). We studied 1584 T2DM patients aged 20 years and older. CA and CP were detected using ultrasonography. Ten-year stroke and CHD risk were determined using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. The prevalence of CA and CP increased gradually with age. Men had a higher prevalence of CA than women (CA: 58.18% vs 51.54%, P < .01). The 10-year CHD risk (27.9% vs 15.4%, P < .001) and stroke risk (15.2% vs 5.70%, P < .001) were higher in patients with CA than that of those without CA. Compared with patients without CA, the odds ratios (ORs) of CHD in CA and CP group were 4.47 and 10.78 for men, and 4.19 and 5.20 for women, respectively; in the case of stroke, the OR in CA and CP group were 8.83 and 12.07 for men, and 4.35 and 4.90 for women, respectively (P < .001 for all). Multivariate binary logistic regression analysis showed that CA was an independent risk factor for CHD [OR = 2.66, 95% confidence interval (95% CI), 2.05–3.46, P < .001] and stroke (OR = 3.11, 95% CI, 2.38–4.07, P < .001). CA and CP were prevalent in patients with T2DM and positively correlated with 10-year CHD and stroke risk. CA was an independent risk factor for 10-year CHD risk.
影响因子：
5.9
作者：
Seon CS;Min KW;Lee SY;Nho KW;Park SH;Koo BK;Han KA
通讯作者：
Han KA
影响因子：
1.9
作者：
Baroncini LA;de Oliveira A;Vidal EA;França GJ;Stahlke PS;Alessi A;Précoma DB
通讯作者：
Précoma DB