Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.
Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.
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作者：
淋巴细胞在激活过程中通过运输程序（粘附和趋化受体的组合）被印记，这些程序将其迁移到特定的组织和微环境。细胞因子有所贡献，但对于肠道和皮肤来说，进化巧妙地适应了来自食物（维生素 A）和阳光（紫外线诱导的维生素 D3）的外部线索，以印记淋巴细胞归巢到小肠和 T 细胞迁移到表皮。树突细胞至关重要：它们将维生素加工成活性代谢物（视黄酸和 1,25(OH)2D3），以将抗原呈递给淋巴细胞，并且它们有助于通过淋巴管将环境信号输出到引流淋巴结，以编程初始 T 和 B 细胞的运输和效应器功能。
Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)2D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.
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DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
DOI：
10.1111/j.1749-6632.2003.tb06057.x
发表时间：
2003-01-01
期刊：
IMMUNE MECHANISMS AND DISEASE
影响因子：
--
作者：
Adorini, L
通讯作者：
Adorini, L
影响因子：
4.4
作者：
Eksteen, Bertus;Miles, Alice;Adams, David H.
通讯作者：
Adams, David H.
影响因子：
5.4
作者：
Dudda, JC;Lembo, A;Martin, SF
通讯作者：
Martin, SF