A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression.
A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression.
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成人孤独症结局研究的荟萃分析：量化效应大小、质量和荟萃回归。
DOI：
10.1007/s10803-020-04763-2
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发表时间：
2021-09
影响因子：
3.9
通讯作者：
Happé F
中科院分区：
文献类型：
--
作者：
Mason D;Capp SJ;Stewart GR;Kempton MJ;Glaser K;Howlin P;Happé F
纵向研究通常报告了大多数自闭症患者（约50 -60%）成年后的不良结局。有几个因素可以预测结果（如智商），但结果仍然是混合的。本文介绍了一个更新的荟萃分析自闭症的结果研究，并扩展了以前的研究结果与额外的分析（包括元回归）。共筛选了4088条记录，18项研究，涉及1199人，被纳入定量分析。估计的百分比表明，20.0%的参与者被评为具有良好的结果，26.6%的结果是公平的，49.3%的结果是差的。荟萃回归分析表明，较低的智商在成年期是预测不良的结果，其他荟萃回归模型没有生存的多重比较校正。总的来说，自闭症患者的结果平均很差，较高的智商似乎可以防止结果不好。目前的结构的结果的局限性进行了讨论。本文的在线版本（10.1007/s10803-020-04763-2）包含补充材料，可供授权用户使用。
Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed. The online version of this article (10.1007/s10803-020-04763-2) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Gillespie-Lynch K;Sepeta L;Wang Y;Marshall S;Gomez L;Sigman M;Hutman T
通讯作者：
Hutman T
影响因子：
3.9
作者：
Bishop-Fitzpatrick, Lauren;Hong, Jinkuk;Mailick, Marsha R.
通讯作者：
Mailick, Marsha R.
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N
影响因子：
6.3
作者：
Barendregt, Jan J.;Doi, Suhail A.;Vos, Theo
通讯作者：
Vos, Theo
DOI：
10.21307/sjcapp-2018-006
发表时间：
2018
影响因子：
1.9
作者：
Jónsdóttir SL;Brynjarsdóttir B;Saemundsen E;Sigurdsson JF
通讯作者：
Sigurdsson JF