Association between Socioeconomic Status and Digestive Tract Cancers: A Case-Control Study.
Association between Socioeconomic Status and Digestive Tract Cancers: A Case-Control Study.
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社会经济地位与消化道癌的关系：病例对照研究。
DOI：
10.3390/cancers12113258
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发表时间：
2020-11-04
期刊：
影响因子：
5.2
通讯作者：
Matsuo K
中科院分区：
文献类型：
--
作者：
Kawakatsu Y;Koyanagi YN;Oze I;Kasugai Y;Morioka H;Yamaguchi R;Ito H;Matsuo K
社会经济地位(SES)与癌症风险之间的关系已有报道，但在亚洲知之甚少。我们揭示了包括教育水平和区域剥夺指数(ADI)在内的SES与日本消化道癌之间的关联。较低的SES与患消化道癌的风险增加相关。对于胃癌，在对幽门螺杆菌感染和/或萎缩性胃炎状态进行额外调整后，与ADI的正相关消失。癌症预防政策应通过将SES整合到目标人群中来考虑个人和区域的视角。尽管社会经济地位(SES)与癌症风险有关，但在日本，关于这种联系的研究很少。为了评估SES与消化道癌症风险的关系，我们在爱知癌症中心III(HERPACC III)基于医院的流行病学研究计划的框架内，对3188例头颈部、食道癌、胃癌和结直肠癌患者以及相同数量的年龄和性别匹配的对照组进行了一项病例对照研究。以受教育程度和地区剥夺指数(ADI)作为SES的指标。通过调整潜在混杂因素的条件Logistic模型，用优势比(OR)和95%可信区间(CI)来评估这种相关性。即使在考虑了已知的癌症风险因素后，教育水平与头颈部、胃癌和结直肠癌也呈线性负相关。与受过初中教育的人相比，受过高等教育的人患癌症的风险显著降低(头颈部0.43(95%CI：0.27-0.68)，胃0.52(0.38-0.69)，结直肠癌0.52(0.38-0.71))。与这些教育水平的结果一致的是，五分位数的ADI与头颈部、食道癌和胃癌呈正相关(p趋势：头颈部p=0.035，食道癌p=0.02，胃癌p=0.013)。有趣的是，在对幽门螺杆菌感染和/或萎缩性胃炎状态进行额外调整后，ADI和胃癌风险之间的正相关消失了。总而言之，在日本，较低的SES与患消化道癌的风险增加有关，应在目标人群的癌症预防政策中加以考虑。
An association between socioeconomic status (SES) and cancer risk has been reported, but little is known in Asia. We revealed an association between SES, including education level and areal deprivation index (ADI), and digestive tract cancers in Japan. Lower SES was associated with an increased risk of digestive cancers. For stomach cancer, the positive association with ADI disappeared following an additional adjustment of Helicobacter pylori infection and/or atrophic gastritis status. Cancer prevention policy should consider both individual and regional perspectives by the integration of SES in the target population. Although socioeconomic status (SES) has been associated with cancer risk, little research on this association has been done in Japan. To evaluate the association between SES and digestive tract cancer risk, we conducted a case-control study for head and neck, esophageal, stomach, and colorectal cancers in 3188 cases and the same number of age- and sex-matched controls within the framework of the Hospital-based Epidemiological Research Program at Aichi Cancer Center III (HERPACC III). We employed the education level and areal deprivation index (ADI) as SES indicators. The association was evaluated with odds ratios (ORs) and 95% confidence intervals (CIs) by conditional logistic models adjusted for potential confounders. Even after allowance for known cancer risk factors, the education level showed linear inverse associations with head and neck, stomach, and colorectal cancers. Compared to those educated to junior high school, those with higher education showed statistically significantly lower risks of cancer (0.43 (95% CI: 0.27–0.68) for head and neck, 0.52 (0.38–0.69) for stomach, and 0.52 (0.38–0.71) for colorectum). Consistent with these results for the educational level, the ADI in quintiles showed positive associations with head and neck, esophageal, and stomach cancers (p-trend: p = 0.035 for head and neck, p = 0.02 for esophagus, and p = 0.013 for stomach). Interestingly, the positive association between ADI and stomach cancer risk disappeared in the additional adjustment for Helicobacter pylori infection and/or atrophic gastritis status. In conclusion, a lower SES was associated with an increased risk of digestive cancers in Japan and should be considered in cancer prevention policies for the target population.
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影响因子：
6.2
作者：
Doubeni CA;Laiyemo AO;Major JM;Schootman M;Lian M;Park Y;Graubard BI;Hollenbeck AR;Sinha R
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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