TLR signaling in mast cells: common and unique features.
TLR signaling in mast cells: common and unique features.
复制标题
DOI：
10.3389/fimmu.2012.00185
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Bulfone-Paus S
中科院分区：
文献类型：
--
作者：
Sandig H;Bulfone-Paus S
除了肥大细胞在对多细胞寄生虫的免疫中以及在变态反应和哮喘的发病机制中的众所周知的作用之外，肥大细胞在对细菌和病毒的免疫防御中的重要性正日益被认识到。它们在皮肤、肠道和气道中的位置使肥大细胞处于理想的位置，以遇到和响应病原体，为了执行这一功能，这些细胞表达多种模式识别受体，包括Toll样受体（TLR）。肥大细胞通过分泌细胞因子、趋化因子和脂质介质对TLR配体作出反应，一些研究发现TLR配体也可引起脱粒，尽管这一发现存在争议。此外，通过TLR配体的刺激可以与通过FcεRI的信号传导协同作用，从而潜在地增强细胞对体内抗原的应答。现在对TLR信号通路有了很多了解。然而，这些通路的一些特征是细胞类型特异性的，并且正在进行工作以充分阐明肥大细胞中的TLR信号级联。已经发现了一些有趣的差异。本文综述了肥大细胞对TLR配体的反应及其信号通路的研究进展。鉴于肥大细胞在暴露于环境的部位的位置，这些细胞对TLR配体的反应必须仔细调节。这一规定背后的已知机制也在这里进行审查。
In addition to the well known role of mast cells in immunity to multi-cellular parasites and in the pathogenesis of allergy and asthma, the importance of mast cells in the immune defense against bacteria and viruses is increasingly being recognized. Their location in the skin, gut, and airways puts mast cells in an ideal location to encounter and respond to pathogens, and in order to perform this function, these cells express a variety of pattern recognition receptors, including Toll-like receptors (TLRs). Mast cells respond to TLR ligands by secreting cytokines, chemokines, and lipid mediators, and some studies have found that TLR ligands can also cause degranulation, although this finding is contentious. In addition, stimulation via TLR ligands can synergize with signaling via the FcεRI, potentially enhancing the response of the cells to antigen in vivo. A great deal is now known about TLR signaling pathways. Some features of these pathways are cell type-specific, however, and work is under way to fully elucidate the TLR signaling cascades in the mast cell. Already, some interesting differences have been identified. This review aims to address what is known about the responses of mast cells to TLR ligands and the signaling pathways involved. Given the location of mast cells at sites exposed to the environment, the response of these cells to TLR ligands must be carefully regulated. The known mechanisms behind this regulation are also reviewed here.
登录
查看更多内容
影响因子：
30.5
作者：
Hamerman, JA;Tchao, NK;Lanier, LL
通讯作者：
Lanier, LL
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.bbrc.2007.10.136
发表时间：
2008-01-04
影响因子：
3.1
作者：
Jayawardana, Sumanasiri T. M.;Ushio, Hiroko;Ogawa, Hideoki
通讯作者：
Ogawa, Hideoki
影响因子：
100.3
作者：
Blander, J. Magarian;Sander, Leif E.
通讯作者：
Sander, Leif E.
DOI：
10.1073/pnas.0912551107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Dietrich, Nicole;Rohde, Manfred;Gekara, Nelson O.
通讯作者：
Gekara, Nelson O.