HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies.
HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies.
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DOI：
10.1007/s11904-022-00605-1
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发表时间：
2022-06
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
This review focuses on the cerebrospinal fluid (CSF) findings in connection to the central nervous system (CNS) reservoir in treatment-naïve and virally-suppressed PLWH, followed by the findings in CSF HIV −1 escape and analytical treatment interruption studies. Compared to chronic infection, initiating antiretroviral therapy (ART) during acute HIV-1 infection results in more homogeneous longitudinal benefits in the CNS. Viral variants in CSF HIV-1 escape are independently linked to infected cells from the systemic reservoir and in the CNS, highlighting the phenomenon as a consequence of different mechanisms. HIV-infected cells persist in CSF in nearly half of the individuals on stable ART and are associated with worse neurocognitive performance. Future studies should probe into the origin of the HIV-infected cells in the CSF. Examining the capacity for viral replication would provide new insight into the CNS reservoir and identify strategies to eradicate it or compensate for the insufficiency of ART.
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影响因子：
6.4
作者：
Avalos CR;Abreu CM;Queen SE;Li M;Price S;Shirk EN;Engle EL;Forsyth E;Bullock BT;Mac Gabhann F;Wietgrefe SW;Haase AT;Zink MC;Mankowski JL;Clements JE;Gama L
通讯作者：
Gama L
影响因子：
6.7
作者：
Clarridge KE;Blazkova J;Einkauf K;Petrone M;Refsland EW;Justement JS;Shi V;Huiting ED;Seamon CA;Lee GQ;Yu XG;Moir S;Sneller MC;Lichterfeld M;Chun TW
通讯作者：
Chun TW
影响因子：
3.8
作者：
Garvey, Lucy J.;Pavese, Nicola;Winston, Alan
通讯作者：
Winston, Alan
影响因子：
3.7
作者：
Gisslen M;Keating SM;Spudich S;Arechiga V;Stephenson S;Zetterberg H;Di Germanio C;Blennow K;Fuchs D;Hagberg L;Norris PJ;Peterson J;Shacklett BL;Yiannoutsos CT;Price RW
通讯作者：
Price RW
影响因子：
82.9
作者：
Colby DJ;Trautmann L;Pinyakorn S;Leyre L;Pagliuzza A;Kroon E;Rolland M;Takata H;Buranapraditkun S;Intasan J;Chomchey N;Muir R;Haddad EK;Tovanabutra S;Ubolyam S;Bolton DL;Fullmer BA;Gorelick RJ;Fox L;Crowell TA;Trichavaroj R;O'Connell R;Chomont N;Kim JH;Michael NL;Robb ML;Phanuphak N;Ananworanich J;RV411 study group
通讯作者：
RV411 study group