Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasma
Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasma
复制标题
加氏乳杆菌：对小鼠肠道菌群酶活性以及盲肠和血浆中异黄酮类化合物的影响
DOI：
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发表时间：
2004
影响因子：
3.6
通讯作者：
K. Shinohara
中科院分区：
文献类型：
--
作者：
M. Tamura;M. Ohnishi;K. Shinohara
研究了加塞乳杆菌JCM 1131T对成年小鼠盲肠和血浆中异黄酮类化合物含量的影响。雄性5周龄小鼠饲喂AIN 93M饲料30d，两组小鼠在解剖前每天分别给予加瑟氏乳杆菌JCM 1131T(LGI组)和生理盐水(CI组)5d。LGI组血浆大豆苷元浓度显著高于CI组，而血浆Equol浓度显著低于CI组。CI组在盲肠中以苷元形式存在的马酚总量显著增加，但以盲肠苷元形式存在的大豆苷元总量无显著差异。在大豆苷与小鼠粪便菌群的体外孵育中，CI组的马酚浓度显著高于CI组。LGI组的乳酸菌数量显著高于对照组。目前的数据表明，给药可能通过改变胃肠道环境来影响异黄酮类化合物对宿主的影响。
The effects of Lactobacillus gasseri JCM 1131T on isoflavonoid levels within the caecum and plasma were assessed in adult mice. Male 5-week-old mice were fed an AIN 93M diet for 30 d. Two groups of mice were administered either L. gasseri JCM 1131T (the LGI group) or physiological saline solution (the control (CI) group) daily for 5 d before dissection. The plasma daidzein concentration was significantly higher in the LGI group, however, their plasma equol concentration was significantly less than in the CI group. The total amount of equol present as aglycone in the caecum was significantly greater in the CI group, but there was no significant difference in the total daidzein present as caecal aglycone. In an in vitro incubation of daidzin with the faecal flora of mice, the equol concentration was significantly higher in the CI group. The numbers of lactobacilli present were significantly higher in the LGI group. The present data suggest that the administration of L. gasseri is likely to influence the effect of isoflavonoids on the host via changes in the gastrointestinal environment.
影响因子：
7.1
作者：
Anthony, MS;Clarkson, TB;Williams, JK
通讯作者：
Williams, JK
影响因子：
7.1
作者：
Setchell, KDR;Brown, NM;Heubi, JE
通讯作者：
Heubi, JE
影响因子：
4.2
作者：
Blair, RM;Appt, SE;Clarkson, TB
通讯作者：
Clarkson, TB