Molecular signatures of longevity: Insights from cross-species comparative studies.
Molecular signatures of longevity: Insights from cross-species comparative studies.
复制标题
DOI：
10.1016/j.semcdb.2017.08.007
复制
发表时间：
2017-10
影响因子：
7.3
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Ma S;Gladyshev VN
目前关于长寿的研究大多集中在单一物种的衰老过程上。几种分子参与者（如IGF1和MTOR）、药理学化合物（如雷帕霉素和二甲双胍）和饮食方法（如热量限制和甲硫氨酸限制）已被证明在调节和适度延长模型生物体寿命方面很重要。另一方面，自然寿命在物种之间的差异要大得多。仅在哺乳动物中，最大寿命的差异就超过100倍，但对潜在的调控机制仍然知之甚少。最近的比较研究开始揭示与长寿相关的分子特征。这些研究包括微蝙蝠、裸鼹鼠、盲鼹鼠、露脊鲸和非洲绿松石鳉的基因组测序，以及对多个哺乳动物物种的基因表达、代谢物、脂质和离子的比较分析。总之，他们指出了几个假定的寿命调节和癌症抗性的策略，以及与寿命变化相关的途径和代谢物。特别是，长寿可能是通过血统特异性适应和适用于整个物种的共同机制来实现的。将由此产生的跨物种分子特征与物种内寿命延长策略进行比较，将提高我们对寿命控制机制的理解，并为新的有效干预措施提供起点。
Much of the current research on longevity focuses on the aging process within a single species. Several molecular players (e.g. IGF1 and MTOR), pharmacological compounds (e.g. rapamycin and metformin), and dietary approaches (e.g. calorie restriction and methionine restriction) have been shown to be important in regulating and modestly extending lifespan in model organisms. On the other hand, natural lifespan varies much more significantly across species. Within mammals alone, maximum lifespan differs more than 100 fold, but the underlying regulatory mechanisms remain poorly understood. Recent comparative studies are beginning to shed light on the molecular signatures associated with exceptional longevity. These include genome sequencing of microbats, naked mole rat, blind mole rat, bowhead whale and African turquoise killifish, and comparative analyses of gene expression, metabolites, lipids and ions across multiple mammalian species. Together, they point towards several putative strategies for lifespan regulation and cancer resistance, as well as the pathways and metabolites associated with longevity variation. In particular, longevity may be achieved by both lineage-specific adaptations and common mechanisms that apply across the species. Comparing the resulting cross-species molecular signatures with the within-species lifespan extension strategies will improve our understanding of mechanisms of longevity control and provide a starting point for novel and effective interventions.
登录
查看更多内容
哺乳动物最大寿命的脂质组决定因素
影响因子：
4.6
作者：
Bozek K;Khrameeva EE;Reznick J;Omerbašić D;Bennett NC;Lewin GR;Azpurua J;Gorbunova V;Seluanov A;Regnard P;Wanert F;Marchal J;Pifferi F;Aujard F;Liu Z;Shi P;Pääbo S;Schroeder F;Willmitzer L;Giavalisco P;Khaitovich P
通讯作者：
Khaitovich P
影响因子：
7.8
作者：
Baumgart M;Groth M;Priebe S;Savino A;Testa G;Dix A;Ripa R;Spallotta F;Gaetano C;Ori M;Terzibasi Tozzini E;Guthke R;Platzer M;Cellerino A
通讯作者：
Cellerino A
影响因子：
8.8
作者：
Fang X;Seim I;Huang Z;Gerashchenko MV;Xiong Z;Turanov AA;Zhu Y;Lobanov AV;Fan D;Yim SH;Yao X;Ma S;Yang L;Lee SG;Kim EB;Bronson RT;Šumbera R;Buffenstein R;Zhou X;Krogh A;Park TJ;Zhang G;Wang J;Gladyshev VN
通讯作者：
Gladyshev VN
影响因子：
2.9
作者：
Butler, MA;King, AA
通讯作者：
King, AA
DOI：
10.1073/pnas.0404998101
发表时间：
2004-08-17
影响因子：
11.1
作者：
Ashur-Fabian, C;Avivi, A;Rechavi, G
通讯作者：
Rechavi, G