Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
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DOI：
10.1111/jgs.16517
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发表时间：
2020-07
影响因子：
6.3
通讯作者：
Bhasin S
中科院分区：
文献类型：
--
作者：
Cawthon PM;Manini T;Patel SM;Newman A;Travison T;Kiel DP;Santanasto AJ;Ensrud KE;Xue QL;Shardell M;Duchowny K;Erlandson KM;Pencina KM;Fielding RA;Magaziner J;Kwok T;Karlsson M;Ohlsson C;Mellström D;Hirani V;Ribom E;Correa-de-Araujo R;Bhasin S
由肌肉减少症定义和结局联盟（SDOC）进行的分析确定了几个握力指标的临界点，以供肌肉减少症定义时考虑。我们描述了SDOC确定的低握力指标（绝对或标准化为身体大小/组成）、文献中先前定义的低双能X线吸收测定法（DXA）瘦体重（apticalleanmass [ALM]/ht 2）和缓慢（步行速度<.8 m/s）与随后不良结局（福尔斯、髋部骨折、活动受限和死亡率）之间的相关性。个体水平、性别分层汇总分析。我们计算了意外福尔斯、活动受限、髋部骨折和死亡率的比值比（OR）或风险比（HR）。随访时间范围为1年（福尔斯）至8.8 ± 2.3年（死亡）。八项前瞻性观察性队列研究。共有13 421名男子和4 828名妇女居住在社区。通过手测力计测量握力，通过DXA测量步态速度和瘦体重。在男性和女性中，低握力（绝对或标准化为身体大小/组成）与事件结局相关，通常与缓慢无关。对于低于临界点与高于临界点的患者，OR和HR通常范围为1.2 - 3.0。DXA瘦体重与这些结果并不一致。当综合考虑时，那些绝对握力（男性<35.5公斤，女性<20公斤）和缓慢的肌肉无力者比那些没有缓慢或肌肉无力的人更容易摔倒，髋部骨折，活动受限或死亡。肌肉无力和行动迟缓的老年男性和女性出现不良健康结果的可能性更高。这些结果支持将握力和步行速度作为肌肉减少症的概括定义的组成部分。
Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cutpoints in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht2); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality). Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 ± 2.3 years for mortality. Eight prospective observational cohort studies. A total of 13,421 community-dwelling men and 4,828 community-dwelling women. Grip strength by hand dynamometry, gait speed, and lean mass by DXA. Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness. Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia.
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影响因子：
6.7
作者：
Dodds RM;Syddall HE;Cooper R;Kuh D;Cooper C;Sayer AA
通讯作者：
Sayer AA
影响因子：
6.3
作者：
Fragala MS;Alley DE;Shardell MD;Harris TB;McLean RR;Kiel DP;Cawthon PM;Dam TT;Ferrucci L;Guralnik JM;Kritchevsky SB;Vassileva MT;Gudnason V;Eiriksdottir G;Koster A;Newman A;Siggeirsdottir K;Satterfield S;Studenski SA;Kenny AM
通讯作者：
Kenny AM
DOI：
10.1093/gerona/glu023
发表时间：
2014-05-01
影响因子：
5.1
作者：
Cawthon, Peggy M.;Peters, Katherine W.;Alley, Dawn E.
通讯作者：
Alley, Dawn E.
影响因子：
5.5
作者：
Duchowny, Kate A.;Peterson, Mark D.;Clarke, Philippa J.
通讯作者：
Clarke, Philippa J.
影响因子：
6.2
作者：
Harvey, Nicholas C.;Oden, Anders;McCloskey, Eugene
通讯作者：
McCloskey, Eugene