Synthetic and natural iron chelators: therapeutic potential and clinical use.
Synthetic and natural iron chelators: therapeutic potential and clinical use.
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DOI：
10.4155/fmc.09.121
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发表时间：
2009-12
影响因子：
4.2
通讯作者：
Torti SV
中科院分区：
文献类型：
--
作者：
Hatcher HC;Singh RN;Torti FM;Torti SV
铁螯合疗法起源于铁超载综合征的治疗。多年来，这个目的的标准是去铁胺。近年来，在鉴定与去铁胺相比具有更好药理特性的合成螯合剂方面取得了相当大的进展。最值得注意的是去铁素（Exjade®）和去铁素（Ferriprox®），这两种药物现已在临床上可用。除了治疗铁超载外，铁螯合剂在治疗以氧化应激为特征的疾病方面也有新的作用，包括心血管疾病、动脉粥样硬化、神经退行性疾病和癌症。虽然铁不被认为是这些疾病的根本原因，但它确实在疾病进展中发挥重要作用，要么通过促进细胞生长和增殖，要么通过参与催化活性氧形成和增加氧化应激的氧化还原反应。因此，铁螯合剂在许多这些情况下可能具有治疗益处。植物化学物质，其中许多结合铁，也可能归功于铁螯合的一些有益特性。本文将重点介绍铁螯合治疗铁超载疾病和癌症以及神经退行性和慢性炎症性疾病的进展。将讨论现有的和新的铁螯合剂，以及膳食植物多酚有效调节铁生物化学的新作用。
Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many years, the standard for this purpose has been deferoxamine. Recently, considerable progress has been made in identifying synthetic chelators with improved pharmacologic properties relative to deferoxamine. Most notable are deferasirox (Exjade®) and deferiprone (Ferriprox®), which are now available clinically. In addition to treatment of iron overload, there is an emerging role for iron chelators in the treatment of diseases characterized by oxidative stress, including cardiovascular disease, atherosclerosis, neurodegenerative diseases and cancer. While iron is not regarded as the underlying cause of these diseases, it does play an important role in disease progression, either through promotion of cellular growth and proliferation or through participation in redox reactions that catalyze the formation of reactive oxygen species and increase oxidative stress. Thus, iron chelators may be of therapeutic benefit in many of these conditions. Phytochemicals, many of which bind iron, may also owe some of their beneficial properties to iron chelation. This review will focus on the advances in iron-chelation therapy for the treatment of iron-overload disease and cancer, as well as neurodegenerative and chronic inflammatory diseases. Established and novel iron chelators will be discussed, as well as the emerging role of dietary plant polyphenols that effectively modulate iron biochemistry.
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影响因子：
4.6
作者：
Cai, Fei;Li, Cai-Rong;Wu, Ji-Liang;Chen, Jian-Guo;Liu, Chao;Min, Qing;Yu, Wei;Ouyang, Chang-Han;Chen, Jin-He
通讯作者：
Chen, Jin-He
影响因子：
2.3
作者：
Beutler, Emest
通讯作者：
Beutler, Emest
影响因子：
7.1
作者：
Aigner, Elmar;Theurl, Igor;Weiss, Guenter
通讯作者：
Weiss, Guenter
影响因子：
6.5
作者：
AROSIO, P;YOKOTA, M;DRYSDALE, JW
通讯作者：
DRYSDALE, JW
DOI：
10.1016/s1386-1425(03)00344-5
发表时间：
2004-04-01
影响因子：
4.4
作者：
Bernabé-Pineda, M;Ramírez-Silva, MT;Rojas-Hernández, A
通讯作者：
Rojas-Hernández, A