Transmission of GB virus type C via transfusion in a cohort of HIV-infected patients.
Transmission of GB virus type C via transfusion in a cohort of HIV-infected patients.
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GB 病毒 C 型在一群 HIV 感染者中通过输血传播。
DOI：
10.1093/infdis/jis209
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Custer,B
中科院分区：
文献类型：
--
作者：
Vahidnia,Farnaz;Petersen,M;Rutherford,G;Busch,M;Assmann,S;Stapleton,JT;Custer,B
Background.GB virus C (GBV-C) infection is transmitted by blood exposure and associated with lower human immunodeficiency virus (HIV) load and slower HIV disease progression. Few studies describe predictors of acute GBV-C infection following transfusion in HIV-infected patients.Methods.We used a limited-access database from the National Heart Lung and Blood Institute’s Viral Activation Transfusion Study, a randomized controlled trial of leukoreduced versus nonleukoreduced transfusions received by HIV-infected, transfusion-naive patients. Blood samples from 489 subjects were tested for GBV-C markers in pretransfusion and posttransfusion samples. We estimated the risk of acquiring GBV-C RNA and predictors of GBV-C acquisition, using pooled logistic regression.Results.GBV-C RNA was detected ≤120 days following the first transfusion in 22 (7.5%) of 294 subjects who were GBV-C negative before transfusion. The risk of GBV-C RNA acquisition increased with each unit transfused (odds ratio, 1.09; 95% confidence interval, 1.06–1.11). Lower baseline HIV load and use of antiretroviral therapy were associated with subsequent GBV-C RNA acquisition, after control for units of blood transfused. Leukoreduced status of transfused units was not associated with GBV-C transmission.Conclusions.Blood transfusion is associated with a significant risk of GBV-C acquisition among HIV-infected patients. Transmission of GBV-C by blood transfusion was inversely related to HIV load.
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DOI：
10.1001/jama.285.12.1592
发表时间：
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期刊：
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Collier,AC;Kalish,LA;Busch,MP;Gernsheimer,T;Assmann,SF;Lane,TA;Asmuth,DM;Lederman,MM;Murphy,EL;Kumar,P;Kelley,M;Flanigan,TP;McMahon,DK;Sacks,HS;Kennedy,MS;Holland,PV;ViralActivationTransfusionStudyGroup
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