Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models.
Multiscale mechanics of articular cartilage: potentials and challenges of coupling musculoskeletal, joint, and microscale computational models.
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DOI：
10.1007/s10439-012-0598-0
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发表时间：
2012-11
影响因子：
3.8
通讯作者：
Erdemir, A.
中科院分区：
文献类型：
--
作者：
Halloran, J. P.;Sibole, S.;van Donkelaar, C. C.;van Turnhout, M. C.;Oomens, C. W. J.;Weiss, J. A.;Guilak, F.;Erdemir, A.
关键词：
关节软骨在日常活动中承受着巨大的机械载荷。健康的软骨提供承载能力，并调节组织发育、维护和修复的机械生物学过程。多尺度的实验研究提供了对软骨细胞宏观力学功能的基本了解，对软骨细胞微观力学环境的评价，以及力学生物学反应的基础。此外，软骨的计算模型提供了许多空间水平的健康和疾病条件下的实验数据的简明描述，并为机械和生物功能产生了假说。此外，建模和仿真为预测性风险评估、功能障碍管理以及将多个空间尺度联系起来提供了一个平台。基于模拟的软骨研究面临着许多挑战，包括计算负担以及用于模型开发和验证的数据往往不足。该综述概述了从力学系统的角度理解软骨功能的最新建模和模拟方法，并说明了将力学与生物功能联系起来的途径。提供了从身体到微结构的单一尺度的计算表示，并试图探索决定软骨和软骨细胞的力学环境的多尺度载荷分担机制。
Articular cartilage experiences significant mechanical loads during daily activities. Healthy cartilage provides the capacity for load bearing and regulates the mechanobiological processes for tissue development, maintenance, and repair. Experimental studies at multiple scales have provided a fundamental understanding of macroscopic mechanical function, evaluation of the micromechanical environment of chondrocytes, and the foundations for mechanobiological response. In addition, computational models of cartilage have offered a concise description of experimental data at many spatial levels under healthy and diseased conditions, and have served to generate hypotheses for the mechanical and biological function. Further, modeling and simulation provides a platform for predictive risk assessment, management of dysfunction, as well as a means to relate multiple spatial scales. Simulation-based investigation of cartilage comes with many challenges including both the computational burden and often insufficient availability of data for model development and validation. This review outlines recent modeling and simulation approaches to understand cartilage function from a mechanical systems perspective, and illustrates pathways to associate mechanics with biological function. Computational representations at single scales are provided from the body down to the microstructure, along with attempts to explore multiscale mechanisms of load sharing that dictate the mechanical environment of the cartilage and chondrocytes.
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影响因子：
2.4
作者：
Butz, Kent D.;Chan, Deva D.;Neu, Corey P.
通讯作者：
Neu, Corey P.
DOI：
10.1115/1.2953472
发表时间：
2008-10
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Anderson AE;Ellis BJ;Maas SA;Peters CL;Weiss JA
通讯作者：
Weiss JA
DOI：
10.1115/1.4001034
发表时间：
2010-06
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Ateshian GA;Maas S;Weiss JA
通讯作者：
Weiss JA
影响因子：
2.4
作者：
Alexopoulos, LG;Williams, GM;Guilak, F
通讯作者：
Guilak, F
DOI：
10.1115/1.2720918
发表时间：
2007-06-01
影响因子：
1.7
作者：
Ateshian, Gerard A.;Ellis, Benjamin J.;Weiss, Jeffrey A.
通讯作者：
Weiss, Jeffrey A.