Potential risk of asymptomatic osteomyelitis around mandibular third molar tooth for aged people: a computed tomography and histopathologic study.
Potential risk of asymptomatic osteomyelitis around mandibular third molar tooth for aged people: a computed tomography and histopathologic study.
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DOI：
10.1371/journal.pone.0073897
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Miyamoto I;Ishikawa A;Morimoto Y;Takahashi T
本研究的目的是探讨骨矿物质密度与下颌牙槽骨组织病理学特征之间的关系，通过亨斯菲尔德单位 [HU] 和组织病理学对人体进行定量评估。 50 名患者共拔除 56 颗下颌磨牙。术前进行计算机断层扫描，并对提取部位进行皮质骨活检以进行组织病理学评估。平均皮质骨和松质骨放射密度分别为 1846±118 HU 和 926±436 HU。年龄与皮质骨 HU 之间不存在相关性（r = −0.004，P = 0.976）；然而，年龄与松质骨HU之间存在显着相关性（r = 0.574，P<0.0000）。青年组（0~30岁）、中年组（31~60岁）、老年组（61<岁）松质骨差异有统计学意义（P<0.05），而皮质骨无显着差异。组织病理学评估显示，年轻患者组骨髓炎相对较少，而老年患者组尽管没有任何临床症状，但仍显示100%局灶性硬化性骨髓炎。平均骨细胞数/单位骨面积为170.7±82.2。年龄与骨细胞数量呈显着负相关（r = −0.51，P<0.0001）。平均陷窝数/单位皮质骨面积为413.1±130，呈非显着负相关（r = −0.257，P = 0.056）。平均空腔数/皮质骨为242.5±145，无相关性（r = 0.081，P = 0.559）。年轻患者骨细胞数量较多，老年患者皮质骨骨细胞减少（P<0.05）。骨质量可能与活细胞数量有更好的相关性，活细胞数量影响骨愈合。有人认为，多年来，皮质骨的最外层可能由于慢性感染而失去了细胞活性，这可能引发了牙齿周围松质骨的硬化变化。
The purpose of this study was to explore the relationship between bone mineral density and histopathological features of mandibular alveolar bone evaluated quantitatively by Hounsfield units [HU] and by histopathology in human subjects. Fifty-six mandibular molars were extracted in 50 patients. Computed tomography was obtained preoperatively, and a cortical bone biopsy was obtained on the extracted sites for histopathological evaluation. The mean cortical and cancellous bone radiodensity was 1846±118 HU and 926±436 HU, respectively. There was no correlation between age and cortical bone HU (r = −0.004, P = 0.976); however, the correlation between age and cancellous bone HU was significant (r = 0.574, P<0.0000). Significant differences in the cancellous bone between young (0–30 years), middle (31–60 years) and old patient groups (61< years) were evident (P<0.05), whereas the cortical bone presented no significant differences. The histopathological evaluation showed that the young patient group had relatively few osteomyelitis, whereas the old patient group showed 100% focal sclerotic osteomyelitis regardless of the fact that the patients had no clinical symptoms. The mean osteocyte number/unit bone area was 170.7±82.2. Negative correlation between age and osteocyte number was significant (r = −0.51, P<0.0001). Mean lacunae numbers/unit cortical bone area were 413.1±130 with non-significant negative correlation (r = −0.257, P = 0.056). The mean empty lacunae numbers/cortical bone were 242.5±145, with no correlation (r = 0.081, P = 0.559). The young patients had high osteocyte number, whereas the old patients showed reduction of the osteocytes in the cortical bone (P<0.05). Bone quality might correlate better to viable cell numbers, which influenced the osseous healing. It is suggested that the outermost layer of cortical bone may have lost its cellular activities over the years due to chronic infection, which may have provoked sclerotic changes in the cancellous bone around tooth.
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影响因子：
4.3
作者：
FRIBERG, B;SENNERBY, L;LEKHOLM, U
通讯作者：
LEKHOLM, U
影响因子：
4.3
作者：
Bartold, P. M.;Kuliwaba, J. S.;Fazzalari, N. L.
通讯作者：
Fazzalari, N. L.
DOI：
10.1016/j.tripleo.2004.06.001
发表时间：
2005-03-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Queral-Godoy, E;Valmaseda-Castell贸n, E;Gay-Escoda, C
通讯作者：
Gay-Escoda, C
影响因子：
4.1
作者：
Lettry, S;Seedhom, BB;Cuppone, M
通讯作者：
Cuppone, M
影响因子：
4.2
作者：
DOTY, SB
通讯作者：
DOTY, SB