Context-dependent effects of a single administration of mirtazapine on the expression of methamphetamine-induced conditioned place preference.
Context-dependent effects of a single administration of mirtazapine on the expression of methamphetamine-induced conditioned place preference.
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DOI：
10.3389/fnbeh.2011.00092
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发表时间：
2011
影响因子：
3
通讯作者：
Napier TC
中科院分区：
文献类型：
--
作者：
Voigt RM;Napier TC
反复接触与冰毒（冰毒）有关的线索会引发戒断性施虐者寻求冰毒并复发。在线索再暴露期间削弱条件性冰毒相关记忆可能为减少复发的药物治疗提供一种手段。因此，我们试图确定非典型抗抑郁药米氮平在再次暴露于情境条件提示时是否会破坏冰毒诱导的条件位置偏好（CPP）的持久性，以及在线索再次暴露时冰毒是否会改变这种效应。首先，我们评估了米氮平在条件反射后12天再次暴露于盐水或冰毒配对的房间时对冰毒诱导的CPP维持的影响。冰毒条件下的大鼠随后给予米氮平表达CPP独立于再次暴露于盐水或冰毒配对的房间；但米氮平处理的大鼠再次暴露于冰毒配对的房间时，CPP的幅度明显减少。接下来，我们评估了米氮平对甲基苯丙胺配对环境“强化再暴露”的影响。在再次暴露于冰毒配对的房间之前，给药米氮平和冰毒没有破坏大鼠在条件反射后15天表现出CPP的能力；然而，当大鼠在再次暴露于冰毒配对的房间之前给予米氮平和冰毒时，CPP被破坏。这些结果表明，如果米氮平治疗与冰毒相关环境下的冰毒给药相结合，米氮平减少冰毒诱导的CPP的能力就会增强，因此，米氮平似乎是在药物相关记忆激活后重新巩固CPP所必需的过程被破坏的结果。
Re-exposure to cues repeatedly associated with methamphetamine (Meth) can trigger Meth-seeking and relapse in the abstinent abuser. Weakening the conditioned Meth-associated memory during cue re-exposure may provide a means for relapse-reduction pharmacotherapy. Accordingly, we sought to determine if the atypical antidepressant mirtazapine disrupted the persistence of Meth-induced conditioned place preference (CPP) when administered in conjunction with re-exposure to contextual conditioning cues, and if this effect was altered by Meth being present during cue re-exposure. First, we evaluated the effect of mirtazapine on the maintenance of Meth-induced CPP during re-exposure to either the saline- or Meth-paired chamber 12 days after conditioning. Meth-conditioned rats subsequently administered mirtazapine expressed CPP independent of re-exposure to the saline- or Meth-paired chamber; but the magnitude of CPP was significantly less for mirtazapine-treated rats re-exposed to the Meth-paired chamber. Next, we evaluated the effect of mirtazapine on a “reinforced re-exposure” to the Meth-paired context. Administration of mirtazapine vehicle and Meth, prior to re-exposure to the Meth-paired chamber did not disrupt the ability of rats to demonstrate CPP 15 days after conditioning; however, CPP was disrupted when rats were administered mirtazapine and Meth prior to re-exposure to the Meth-paired chamber. These results indicate that the capacity of mirtazapine to diminish Meth-induced CPP is promoted if mirtazapine treatment is coupled with Meth administration in the Meth-associated context and thus appears to be the consequence of disrupting processes necessary to reconsolidate CPP following activation of drug-associated memories.
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DOI：
10.1097/00004850-200211000-00009
发表时间：
2002-11-01
影响因子：
2.6
作者：
Bhanji, NH;Margolese, HC;Chouinard, G
通讯作者：
Chouinard, G
影响因子：
5.5
作者：
Boehm, S
通讯作者：
Boehm, S
影响因子：
5
作者：
Eidi, M;Zarrindast, MR;Parivar, K
通讯作者：
Parivar, K
影响因子：
3.4
作者：
EHRMAN, RN;ROBBINS, SJ;OBRIEN, CP
通讯作者：
OBRIEN, CP
影响因子：
3.8
作者：
Cruickshank, Christopher C.;Montebello, Mark E.;Shand, Diana
通讯作者：
Shand, Diana