Microfabricated Probes for Studying Brain Chemistry: A Review.
Microfabricated Probes for Studying Brain Chemistry: A Review.
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DOI：
10.1002/cphc.201701180
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发表时间：
2018-05-22
期刊：
影响因子：
--
通讯作者：
Kennedy RT
中科院分区：
文献类型：
--
作者：
Ngernsutivorakul T;White TS;Kennedy RT
用于监测体内化学的探针技术（例如，电化学传感器和微透析取样探针）显著地有助于更好地理解与行为和神经障碍相关的神经传递。微加工允许构建具有高再现性、可扩展性、设计灵活性和多路复用特征的神经探针。这项技术已经很好地转化为制造用于电化学检测和采样的微型神经化学探针。微加工电化学探针提供了一个更好的控制空间分辨率与多位点检测在一个单一的紧凑的平台。这一发展使得我们能够精确地观察大脑区域内神经化学活性的异质性。微加工取样探针开始出现，使化学测量在高空间分辨率和减少组织损伤的潜力。分析方法的最新进展也促进了高时间分辨率的神经化学监测。此外，微制造探针的一个积极特征是它们可以与其他传感和刺激平台（包括光遗传学）一起可行地构建。这种集成的探针将使研究人员能够精确地阐明大脑功能，并为神经系统疾病开发新的治疗方法。微型神经化学探针：微加工技术作为一种重要的工具出现，用于开发微型，高精度的电化学检测和活体脑组织取样探针。本文综述了适应微制造，创造下一代的神经化学探针的进展和前景。
Probe techniques for monitoring in vivo chemistry (e.g., electrochemical sensors and microdialysis sampling probes) have significantly contributed to a better understanding of neurotransmission in correlation to behaviors and neurological disorders. Microfabrication allows construction of neural probes with high reproducibility, scalability, design flexibility, and multiplexed features. This technology has translated well into fabricating miniaturized neurochemical probes for electrochemical detection and sampling. Microfabricated electrochemical probes provide a better control of spatial resolution with multisite detection on a single compact platform. This development allows the observation of heterogeneity of neurochemical activity precisely within the brain region. Microfabricated sampling probes are starting to emerge that enable chemical measurements at high spatial resolution and potential for reducing tissue damage. Recent advancement in analytical methods also facilitates neurochemical monitoring at high temporal resolution. Furthermore, a positive feature of microfabricated probes is that they can be feasibly built with other sensing and stimulating platforms including optogenetics. Such integrated probes will empower researchers to precisely elucidate brain function and develop novel treatments for neurological disorders. Microfabricated neurochemical probes: Microfabrication technology emerges as an important tool for developing miniature, high precision probes for electrochemical detection and sampling from living brain tissues. This review describes advances and perspectives in adapting microfabrication to create the next generation of neurochemical probes.
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