Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.
Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.
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围产期炎症生物标志物与早产儿呼吸系统疾病
DOI：
10.1016/j.jpeds.2022.04.028
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发表时间：
2022-07
影响因子：
5.1
通讯作者：
Everett, Allen D.
中科院分区：
文献类型：
--
作者：
Collaco, Joseph M.;McGrath-Morrow, Sharon A.;Griffiths, Megan;Chavez-Valdez, Raul;Parkinson, Charlamaine;Zhu, Jie;Northington, Frances J.;Graham, Ernest M.;Everett, Allen D.
目的是测量出生后第一周血浆中血管内皮生长因子（VEGF）以及几种细胞因子（白细胞介素[IL]-6、IL-8、IL-10）的水平，以研究蛋白质表达与发生呼吸窘迫综合征（RDS）和支气管肺发育不良（BPD）可能性之间的关系。
对出生后第一周的早产患者血浆中的IL-6、IL-8、IL-10和VEGF水平进行了测量。研究对象为2009年4月至2019年4月期间从一家中心招募的新生儿。研究标准包括在该中心出生、出生体重低于1500克且出生时胎龄小于32周。
早产新生儿RDS的发生与出生后第一周VEGF水平较低有关。血浆IL-6和IL-8水平较高与月经龄36周时BPD发生可能性增加及病情加重有关。相比之下，出生后第一周测得的VEGF、IL-6、IL-8和IL-10血浆水平与门诊BPD幼儿的呼吸道症状及急诊使用情况无关。
在出生后第一周，血浆VEGF水平较低与早产婴儿RDS的诊断有关。出生后第一周IL-6和IL-8水平较高的早产婴儿也更有可能被诊断为BPD。这些生物标志物可能有助于预测早产新生儿初次住院期间的呼吸疾病情况。
To measure plasma levels of vascular endothelial growth factor (VEGF) and several cytokines (Interleukin [IL]-6 IL-8, IL-10) during the first week of life to examine the relationship between protein expression and likelihood of developing respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). Levels of IL-6, IL-8, IL-10, and VEGF were measured from plasma obtained from preterm patients during the first week of life. Newborns were recruited from a single center between April 2009 and April 2019. Criteria for the study included being inborn, birth weight of less than 1500 grams, and a gestational age of less than 32 weeks at birth. The development of RDS in preterm newborns was associated with lower levels of VEGF during the first week of life. Higher plasma levels of IL-6 and IL-8 plasma were associated with an increased likelihood and increased severity of BPD at 36 weeks postmenstrual age. In contrast, plasma levels of VEGF, IL-6, IL-8, and IL-10 obtained during the first week of life were not associated with respiratory symptoms and acute care use in young children with BPD in the outpatient setting. During the first week of life, lower plasma levels of VEGF was associated with the diagnosis of RDS in preterm infants. Preterm infants with higher levels of IL-6 and IL-8 during the first week of life were also more likely to be diagnosed with BPD. These biomarkers may help to predict respiratory morbidities in preterm newborns during their initial hospitalization.
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影响因子：
1.8
作者：
Lusyati S;Hulzebos CV;Zandvoort J;Sauer PJ
通讯作者：
Sauer PJ
影响因子：
3.1
作者：
Hendricks-Munoz, Karen D.;Xu, Jie;Voynow, Judith A.
通讯作者：
Voynow, Judith A.
影响因子：
8
作者：
Chan, Johnny Y. C.;Stern, Debra A.;Martinez, Fernando D.
通讯作者：
Martinez, Fernando D.
影响因子：
8
作者：
McGrath-Morrow, Sharon A.;Lee, Grace;Collaco, J. Michael
通讯作者：
Collaco, J. Michael
影响因子：
3.4
作者：
Parker, RA;Lindstrom, DP;Cotton, RB
通讯作者：
Cotton, RB